Idhifa side effects | Allevaire India

Like all drugs, Idhifa may cause side effects. The following lists contain some of the key side effects that may occur while taking Idhifa. These lists do not include all possible side effects.

For more information about the possible side effects of Idhifa, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be concerning or bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Idhifa, you can do so through MedWatch.

IDHIFA (Enasidenib) is available.

Mild side effects

The mild side effects* of Idhifa, which can rarely become serious, include:

• nausea or vomiting†
• diarrhea†
• decreased appetite†
• changes in blood levels of calcium, potassium, or phosphorus

increased level of bilirubin (a byproduct of red blood cells that are broken down), which can cause jaundice (yellowing of your skin or the whites of your eyes)

These side effects should be manageable or diminish over time while you’re taking Idhifa. But if any of your side effects become severe or don’t go away, tell your doctor right away.

Also, keep in mind that your doctor may order lab tests to check for certain side effects of Idhifa. So, be sure to keep all appointments for labs and other tests during your Idhifa treatment.

* To learn more about this drug’s side effects, talk with your doctor or pharmacist, or view Idhifa’s prescribing information.

† For more information about this side effect, see “Side effect details” below.

Serious side effects

Serious side effects with Idhifa treatment are common. Call your doctor right away if you have new or unusual symptoms as they may be serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

Tumor lysis syndrome (a condition that occurs when cancer cells release their contents into your body). Symptoms can include:

• restlessness, irritability, confusion, or delirium (change in mental function)
• extreme tiredness
• nausea, vomiting, or diarrhea
• muscle weakness, cramps, or spasms
• tingling in your extremities or around your mouth
• irregular heartbeat

seizures

• Leukocytosis (high white blood cell count).*
• Allergic reaction.*
• Differentiation syndrome.†

* For more information about this side effect, see “Side effect details” below.

† Idhifa has a boxed warning Trusted Source for differentiation syndrome. This is the most serious warning from the FDA. To learn more, see ”Side effect details” below.

Side effect details

Here’s some detail on certain side effects this drug may cause.

Differentiation syndrome

Treatment with Idhifa increases your risk for differentiation syndrome (DS). In fact, Idhifa has a boxed warningTrusted Source for DS. Boxed warnings are the most serious warnings from the Food and Drug Administration (FDA). These warnings alert doctors and patients about drug effects that may be dangerous.

DS is a common serious side effect of Idhifa. It can happen after your first dose of Idhifa or within the first 5 months of treatment.

DS affects your blood cells. And if it’s not treated, it can lead to severe symptoms including organ failure and possibly, death.

There isn’t one medical test alone that doctors can use to diagnose DS. Instead, they order certain labs tests before and during Idhifa treatment to both:

• check on the condition you’re using Idhifa to treat
• monitor for changes in your body that may result from serious side effects including DS

To learn more about your risk for DS with Idhifa treatment, talk with your doctor.

Possible symptoms of DS

While taking Idhifa, seek emergency medical care right away if you have any new or unusual symptoms. Possible symptoms that may occur with DS include:

fever

cough

trouble breathing or breathing more quickly than usual

feeling dizzy or faint

fast weight gain (more than 10 pounds in 1 week)

swelling in your hands, feet, ankles, or lower legs

bone pain

swollen lymph nodes

In addition, DS may cause other serious symptoms or health problems, too.

Management of DS

If your doctor believes you have DS from taking Idhifa, they’ll treat your condition with a corticosteroid that’s either taken by mouth or given as an injection into your vein. An example of a corticosteroid that may be used is dexamethasone (Decadron).

Your doctor will also monitor you until your DS symptoms improve. And depending on your condition, your doctor may have you stay at a hospital or stop treatment with Idhifa.

High white blood cell count

Idhifa may cause leukocytosis (increased white blood cell count). Having an elevated white blood cell count is a possible serious side effect of Idhifa.

Specifically, the drug may cause non-infectious leukocytosis. It’s called non-infectious because it doesn’t happen in response to an infection in your body. Typically, white blood cells help protect you from infection-causing germs.

Typically, having an increased white blood cell count doesn’t cause symptoms. So, to monitor for this side effect, your doctor will order blood tests to check your blood cell counts. They’ll do this before and during your Idhifa treatment. If your white blood cell counts are too high, your doctor may prescribe a drug called hydroxyurea (Droxia, Hydra, Siklos). Hydroxyurea can help lower your white blood cell count.

If your white blood cell count doesn’t go down with hydroxyurea treatment, your doctor may have you stop taking Idhifa. And they may have you restart treatment with Idhifa once your white blood cell count is within a normal range.

Gastrointestinal side effects

While you’re taking Idhifa, you may have certain gastrointestinal (GI) side effects. (GI side effects are related to your digestive system.) These are common side effects of Idhifa.

GI side effects that may occur with Idhifa include:

nausea

vomiting

diarrhea

decreased appetite

changes in taste

If you have mild GI side effects that bother you, talk with your doctor or pharmacist. They may recommend prescription or over-the-counter drugs to help manage certain side effects like nausea or vomiting. Or, they may recommend non-drug treatments, such as electrolyte drinks or a bland diet. Be sure to check with your doctor before trying any medications for GI side effects.

If you have severe nausea, vomiting, or diarrhea, call your doctor right away. These side effects could be serious, and they may lead to severe dehydration or other health problems. (With dehydration, you have a low level of fluid in your body.)

ENTYVIO (VEDOLIZUMAB) 300MG INJECTION Warnings

Entyvio warnings

Before taking Entyvio, talk with your doctor about any medical conditions you have. Entyvio may not be appropriate for you if you have certain medical conditions.

• For people with infections: Entyvio can worsen infections. If you have symptoms of an infection, such as a fever or cough, you may not be able to use Entyvio until the infection has cleared.
• For people with liver disease: Entyvio may worsen liver problems in those who already have liver disease. It can also cause liver damage.
• For people who’ve had an allergic reaction or infusion reaction: Some people have allergic reactions or infusion reactions when ENTYVIO (VEDOLIZUMAB) 300MG INJECTION
   is given. See the “Entyvio side effects” section above for information. If you have had an allergic or infusion reaction to Entyvio, your doctor will likely recommend that you avoid this medication.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

ENTYVIO 

How to prepare for an Entyvio infusion

Entyvio infusion

Entyvio is given as an intravenous (IV) infusion. This means it needs to be given in your doctor’s office, hospital, or infusion center.

Before your appointment

Your doctor or nurse will give your specific instructions on how to prepare for the infusion, but here are some tips:

Drink fluids. Be sure to drink plenty of fluids the day or two before your infusion appointment. For most people, this should be six to eight glasses of water or fluids daily. Try to avoid drinking too much caffeine, which can cause fluid loss.

Tell your doctor. If you have symptoms of an infection, such as cough or fever, be sure to let your doctor know. Also tell your doctor if you’re taking antibiotics. In either case, you may need to reschedule your infusion.

Arrive early. For your first infusion, plan to arrive 15 to 20 minutes early to complete paperwork, if needed.

ENTYVIO (VEDOLIZUMAB) 300MG INJECTION

Come prepared. This includes:

Dressing in layers. Some people feel cold while receiving their infusion.

Bringing a snack or lunch. Although the infusions don’t last very long, you may want to eat if you’re having the infusion over your lunch break.

Bringing your mobile device, headphones, or a book if you want to have entertainment during the infusion.

Knowing your schedule. If you have an upcoming vacation or other times you’ll be unavailable, your appointment is a good time to finalize future infusion dates.

What to expect

During your appointment, you’ll receive an IV. Once the IV is inserted into your vein, the infusion itself usually lasts about 30 minutes.

Once the infusion is completed, you can return to work or normal daily activities. Some people have mild side effects following an infusion, such as:

tenderness or bruising at the IV site

cold-like symptoms

• headache
• fatigue
• nausea
• joint pain
• rash

Allergic reaction and infusion reaction

Some people have allergic reactions or infusion reactions when Entyvio is given. These are usually not severe, but may be severe in some cases.

Administration of Entyvio will need to be stopped if a severe reaction occurs. These reactions can happen after the first dose of Entyvio or later doses.

Symptoms may include:

• trouble breathing
• itchy skin
• flushing
• rash
• hives
• fast heart rate
• increased blood pressure

If you have symptoms of an allergic or infusion reaction after receiving ENTYVIO (VEDOLIZUMAB) 300MG INJECTION

, call your doctor. But if your symptoms feel life threatening, call 911 or have someone take you to the emergency room.

ENTYVIO (VEDOLIZUMAB) 300MG INJECTION

 Entyvio side effects

Entyvio can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking Entyvio. This list does not include all possible side effects.

For more information on the possible side effects of Entyvio, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.

More common side effects

The more common side effects of Entyvio include:

• runny nose
• sore throat
• respiratory infection such as bronchitis or sinus infection
• headache
• joint pain
• nausea
• fever
• fatigue
• cough
• flu
• back pain
• rash or itchy skin

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Allergic reaction and infusion reaction. Some people have allergic reactions or infusion reactions when Entyvio is given. These are usually not severe, but may be severe in some cases. Administration of Entyvio will need to be stopped if a severe reaction occurs. These reactions can happen after the first dose of Entyvio or later doses. Symptoms may include:

• trouble breathing
• itchy skin
• flushing
• rash
• hives
• fast heart rate
• increased blood pressure

Liver damage. Some people who receive Entyvio can experience liver damage. If you develop liver damage symptoms, your doctor may stop your treatment with Entyvio. Symptoms of liver damage can include:

yellowing of your skin or the whites of your eyes

• fatigue
• stomach pain

Cancer. During studies of Entyvio, about 0.4 percent of those who received Entyvio developed cancer compared to about 0.3 percent who received a placebo. Whether Entyvio increases the risk of cancer isn’t clear.

Infections. People who take Entyvio have an increased risk of infection, such as the common cold or flu. More serious infections may also occur. These might include tuberculosis or an infection in the brain called progressive multifocal leukoencephalopathy (see below). If you develop a severe infection while taking Entyvio, you may need to stop taking the medication until the infection has been treated.

ENTYVIO (VEDOLIZUMAB) 300MG INJECTION

Side effect details

You may wonder how often certain side effects occur with this drug. Here’s some detail on certain side effects this drug may cause.

PML

Progressive multifocal leukoencephalopathy (PML) is a serious viral infection of the brain. It typically only happens in people whose immune system isn’t fully functioning.

During studies, PML did not occur in anyone who took Entyvio. However, it has occurred in people receiving medications that are similar to Entyvio, such as Tysabri (natalizumab).

While you take Entyvio, your doctor will monitor you for symptoms of PML. These symptoms may include:

• weakness on one side of your body
• vision problems
• clumsiness
• memory problems
• confusion

If you have questions or concerns about this potential side effect, talk with your doctor or pharmacist.

Hair loss

Hair loss isn’t a side effect that has occurred in studies of Entyvio. However, some people have had hair loss while taking Entyvio. It’s not clear if Entyvio is the cause of hair loss. If you have questions or concerns about this potential side effect, talk with your doctor or pharmacist.

Weight gain

Weight gain isn’t a side effect that has occurred in studies of Entyvio. However, some people who take Entyvio say that they gain weight. Gaining weight may be the result of healing in the gut, especially for those who’ve lost weight due to a flare-up of symptoms of the condition being treated. If you have questions or concerns about weight gain during your treatment, talk with your doctor or pharmacist.

ENTYVIO (VEDOLIZUMAB) 300MG INJECTION USES

 Entyvio uses

The Food and Drug Administration (FDA) approves prescription drugs such as Entyvio to treat certain conditions.

Entyvio is FDA-approved to treat two conditions: ulcerative colitis (UC) and Crohn’s disease.

Entyvio for ulcerative colitis

Entyvio is used to improve symptoms and cause symptom remission in people with moderate to severe UC. It’s prescribed for people who don’t have enough improvement with other medications, or who can’t take other medications.

Effectiveness for treating ulcerative colitis

For UC, clinical studies have found Entyvio to be effective in causing symptom remission.

Guidelines from the American Gastroenterological Association recommend using a biologic agent such as vedolizumab (the active drug in Entyvio) for inducing and maintaining remission in adults with moderate to severe UC.

Entyvio for Crohn’s disease

Entyvio is used to improve symptoms and cause symptom remission in people with moderate to severe Crohn’s disease. It’s prescribed for people who don’t have enough improvement with other medications, or who cannot take other medications.

Effectiveness for treating Crohn’s disease

For Crohn’s disease, clinical studies have found Entyvio to be effective in bringing about symptom remission.

Guidelines from the American College of Gastroenterology recommend vedolizumab (the active drug in Entyvio) for inducing remission and healing the gut in adults with moderate to severe active Crohn’s disease.

Entyvio for children

Entyvio is not FDA-approved for use in children. However, some doctors may use Entyvio off-label for treating UC or Crohn’s disease in children.

One study found that Entyvio caused remission of symptoms in 76 percent of children with UC, and 42 percent of children with Crohn’s disease. More research is needed to know Entyvio’s safety and effectiveness in children.

Entyvio generic

Entyvio contains the drug vedolizumab. Vedolizumab isn’t available as a generic drug. It’s only available as Entyvio.

ENTYVIO (VEDOLIZUMAB) 300MG INJECTION

How to use and side effects Abirapro 250mg tablet:

 Side effects are unwanted symptoms caused by medical treatment. Although all medicines can cause side effects, everyone will not get them.

Serious:

• Muscle weakness
• Muscle twitches
• Palpitations
• Lung irritation
• Failure of liver to function
• Adrenal gland problems
• Abnormal heart rhythm
• Heart attack
• Changes in the electrocardiogram
• Serious allergic reactions with difficulty in swallowing or breathing
• Swollen face, lips, tongue, or throat
• Itchy rash
• Bone loss

Common

• Fluid in legs or feet
• Low blood potassium
• Liver function test increases
• High blood pressure
• Urinary tract infection
• Diarrhea
• High-fat levels in the blood
• Chest pain
• Irregular heartbeat
• Heart failure
• Rapid heart rate
• Severe infections
• Bone fracture
• Indigestion
• Blood in urine
• Rash

Abirapro 250mg tablet

How to use Abirapro 250mg tablet: 

The medicine should always be consumed as per the direction of your physician or pharmacist. The drug should be taken by mouth. It should not be taken with food. Swallow the tablets whole with water without breaking them. The drug should be taken with prednisone or prednisolone every day while taking Abirapro 250mg tablet. The amount of prednisone or prednisolone will be as per the doctor’s advice. The discontinuation of prednisone or prednisolone will also be as per the doctor’s advice. If more than one Abirapro 250mg tablet is consumed, the patient should inform the doctor.

Safety Advice:

Driving:

This medicine is not likely to affect driving and the use of any tools or machines.

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 ABIRAPRO 250 MG  IS THE GENERIC VERSION OF ZYTIGA (ABIRATERONE ACETATE)

ABIRAPRO  250mg – Abiraterone Acetate is a drug used in combination with prednisone in metastatic castration-resistant prostate cancer (formerly hormone-resistant prostate cancer) which is a prostate cancer not responding to androgen deprivation or treatment with anti-androgens.

Abirapro (Abiraterone Acetate 250mg ) works by inhibiting specific “enzymes” in your adrenal glands that are responsible for making androgens. For this reason, there is an increased risk of over production of mineral corticosteroids in your body while on Abirapro (Abiraterone acetate).

As a result, Abirapro (Abiraterone Acetate 250mg) may cause hypertension [high blood pressure], hypokalemia [low levels of potassium in the blood], and fluid retention.
Because of this risk, Abirapro (Abiraterone acetate) should be used cautiously in patients with a strong cardiovascular history, and patients should be monitored closely for these symptoms. Dosing along with prednisone will decrease the risk of mineralocorticoid excess.

 

ABIRAPRO TABLET

ABIRAPRO INDICATION & DOSAGE:

Abirapro (Abiraterone acetate) is a pill, taken by mouth. It is taken once a day. Abirapro must be taken on an empty stomach [2 hours after a meal, or one hour before] .Abirapro  should be taken at approximately the same time each day. Prednisone [10mg daily] should be taken along with Abirapro (Abiraterone acetate)

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