Darzalex (daratumumab) dosing, indications, interactions ...

What is Darzalex?

Daratumumab is an anti-cancer drug. It binds to CD38, which overexpresses multiple myeloma cells.

Darzalex is a prescription drug used to treat adults with multiple myeloma. It is unclear whether Darzalex is safe and effective in children.

What are the important side effects of Darzalex?

Darzalex may cause serious reactions, including:

1.Infusion reaction. 

Infusion reactions are common in Darzalex and can be severe. If you have an infusion reaction, your health care provider may temporarily stop the infusion or completely stop treatment with Darzalex. If you experience any of the following symptoms, please seek medical help immediately:

• Shortness of breath or difficulty breathing
• Dizziness or lightheadedness (hypotension)
• Cough
• Respite
• Tight throat
• Runny or stuffy nose
• Headache
• Itching
• Nausea
• Vomiting
• Chills
• Heat

2. Blood Test Changes

Darzalex will affect the results of blood tests to match your blood type. After you take the last dose of Darzalex, these changes can last up to 6 months. Before starting treatment with Darzalex, your health care provider will perform a blood test to match your blood type. Before accepting a blood transfusion, please inform all healthcare providers that you are receiving Darzalex treatment.

3. Blood Cell Count Decreases 

Darzalex reduces the number of white blood cells that help fight infection, and blood cells called platelets help clot blood. Your healthcare provider will check your blood count during treatment with Darzalex. If you have a fever or signs of bruising or bleeding, please tell your healthcare provider.

The most common side effects of Darzalex include:

• Tired
• Nausea
• Diarrhea
• Shortness of breath
• Difficulty sleeping
• Feel weak
• Loss of appetite
• Heat
• Cough
• Muscle cramps
• Backache
• Arthralgia
• Vomiting

Tell your healthcare provider if you have any side effects that are bothering you or will not go away.

These are not all possible side effects of Darzalex. Call your doctor for medical advice about side effects. You can report side effects to FDA at 1-800-FDA-1088.

The fact of DARZALEX (Daratumumab) injection 100mg / 5ml and 400mg / 20ml vials?

Medical Name: DARZALEX

Common Name: Daratumumab

Approval Date: November 16, 2015

Company Name: Janssen Biotech

Available Forms and Strengths: 100mg / 5ml and 400mg / 20ml injections

What are the indications and usage?

DARZALEX is a kinase inhibitor suitable for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. Is a monoclonal antibody against human CD38, suitable for the treatment of patients with multiple myeloma, these patients have received at least three previous therapies, including proteasome inhibitors (PI) and immunomodulators, or PI and immunomodulators Double resistance?

The instruction has been approved under accelerated approval based on the response rate

Dosage and Administration

Recommended dosage and schedule

Manage medications before and after infusion.

After dilution in 0.9% sodium chloride injection (USP), it can only be administered as an intravenous infusion.

DARZALEX should be managed by medical staff and should immediately use first aid equipment and appropriate medical support to manage the infusion reactions that occur.

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Multiple Myeloma: Symptoms, Causes, Diagnosis and Treatment

Multiple Myeloma

Multiple myeloma, also called Kahler's disease, is a blood cancer. There is no cure, but treatment can slow its spread and sometimes even make symptoms disappear.

A type of white blood cells called plasma cells produce antibodies that fight infections in the body. When you have multiple myeloma, these cells will multiply in the wrong way. They allow too much protein (called immunoglobulin) to enter the bones and blood.

Plasma Cell Carcinoma

Plasma cells are a type of white blood cell in the bone marrow. In this case, a group of plasma cells will become cancerous and multiply. The disease can damage bones, the immune system, kidneys and the number of red blood cells.

Symptoms may not be present or specific, such as loss of appetite, bone pain and fever.

Treatments include drugs, chemotherapy, corticosteroids, radiation or stem cell transplantation.

Multiple myeloma is a cancer that forms in white blood cells called plasma cells. Plasma cells help you fight infections by making antibodies that recognize and attack bacteria. Multiple myeloma causes cancer cells to accumulate in the bone marrow and crowd out healthy blood cells.

Symptoms: fatigue; fracture; bone pain ...

Plasma Cell Disease

Multiple myeloma is one of many diseases that can cause plasma cell problems. Others include:

• Monoclonal gammopathy. This is when your plasma cells make too many copies of an antibody. Multiple myeloma is a form of this disease. Another form, monoclonal gammopathy of unknown significance, may make you more likely to develop multiple myeloma.
• Solitary plasmacytoma. This is like multiple myeloma, but it causes a single abnormal plasma cell growth, not many of them. It can occur inside or outside the bone. It may also increase the risk of multiple myeloma.
• Light chain amyloidosis. This can cause abnormal plasma cells in your bone marrow, but they are fewer than multiple myeloma.
• Waldenstrom macroglobulinemia. This is a type of monoclonal gamma disease and non-Hodgkin's lymphoma (cancer of the lymphatic system). The cancer cells have the characteristics of plasma cells and lymphoid tissues.

Etiology and risk factors of multiple myeloma

Experts are not sure what causes multiple myeloma. However, you are more likely to obtain it if:

• You are over 65 years old
• You are a male
• You are african american
• You have family
• You are overweight or obese
• You are radiated
• You have been exposed to chemicals used in rubber manufacturing, wood processing or fire fighting; or in herbicides

Symptoms of Multiple Myeloma

Early on, you may not notice any symptoms. But as time goes by, you may:

• Bone pain
• Weakness and fatigue
• Weight loss and loss of appetite
• Upset stomach
• constipation
• confusion
• Frequently infected
• thirst
• Weak or numb arms and legs

Diagnosis of Multiple Myeloma

If you perform other blood tests, your doctor may suspect multiple myeloma and display:

• Excessive calcium in the blood (hypercalcemia)
• Too few red blood cells (anemia)
• Kidney problems
• The total protein level in the blood is high, but a level called albumin is low (your doctor may say you have a "globulin gap")

Multiple Myeloma Complications

Multiple myeloma can cause the following problems:

• Bone problems. Your bones will weaken and cause fractures.
• Blood problems. You may have anemia, which means your body does not have enough red blood cells. This can make you tired, pale, and cause heart disease. You may have too few platelets, which makes your blood more difficult to clot.
• Infection. When you have myeloma, your body produces many weak antibodies, which will reject healthy antibodies, making it more difficult for you to fight infection. Lack of white blood cells also weakens your immune system.
• Kidney damage. Myeloma can block the kidneys and prevent them from filtering the way they should. This may cause kidney failure.

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Named Patient Supply - Licenced Medicines Access Program ...

The Named Patient Program (NPP) provides patients and doctors with commercially approved drugs that are not available in their home country. ... is approved and available in one country, but not approved in the country where the patient is located. Discontinued in the country where the patient is located but not in other countries

Naming patient plan

Alleviare Life Sciences Pvt. Ltd. is a consulting pharmaceutical company that specializes in naming patients. We assist patients to establish contact with real and authorized distributors of special medicines that are not or not approved in India.

Indian generic drugs

If some patients require certain high-quality generic drugs, we will also abide by the highest ethical standards in the way of operation, we will provide a variety of options, and we can provide you with professional convenience.

Provide medicines to patients in need through designated patient supply

Governments around the world have established relevant provisions that allow patients who have exhausted all alternative treatment options and do not meet the criteria for clinical trial entry to use the prescribed patient drug treatment plan before they are approved. These named patient plans are usually categorized by sympathetic use, expanded use, or designated patient supply labels. These rules are governed by national / regional definitions of access standards, data collection, promotion, and drug distribution

 control rules.

Information for patients

What is the procedure for naming patients?

The Named Patient Program (NPP) provides patients and doctors with commercially approved drugs that are not available in their home country. These drugs must be approved in at least one country before they can be imported into the country where the patient is based on NPP.

The medicine is called 2 names?

Many drugs have at least two different names:

Brand name-created by pharmaceutical companies that manufacture drugs.

Generic name – the name of the active ingredient in the medicine.

Use of compassion in medicine

Sympathetic drug use (or sometimes sympathetic drug use) refers to the use of unapproved new drugs to treat critically ill patients when no other treatment is available. Drugs that are being tested but not yet approved by the US Food and Drug Administration (FDA) are called research drugs.

Special license

Special drugs refer to unlicensed drugs that can meet the individual clinical needs of patients when there are no suitable licensed drugs. "Special drugs" account for about 1% of all prescription drugs in the UK, but account for more than 75,000 different prescription drugs.

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India Imports: Medicinal and Pharmaceutical Product

The United States relies heavily on drugs imported from China. Antibiotics, over-the-counter painkillers, and drugs that can relieve itching and swelling-many are imported from China.

Can prescription drugs be imported?

As mentioned above, although individuals are allowed to import their own prescription drugs under limited circumstances, there is no “safe harbour” that allows the import of prescription drugs that violate federal laws, and these drugs are imported for commercial distribution or management of others.

Is it legal for me to import drugs personally?

In most cases, it is illegal for individuals to import drugs into the United States for personal use. ... for example, if a drug is approved by Health Canada (the equivalent of the Canadian FDA) but not yet approved by the FDA, the drug is not approved in the United States, so the import is illegal.

Can I prescribe in another country?

Even if you prepare a copy of the beneficiary and money used to pay for medicines, many countries do not allow pharmacies to fill out prescriptions outside their country. One solution is to have a local doctor explain your condition to obtain a new prescription that can be filled in locally.

Which country's pharmacy is the best?

Top Pharmacy and Pharmacology

Harvard University. ...

University of Cambridge. ...

National University of Singapore, Singapore. ...

University of Oxford. ...

Karolinska Institute of Sweden. ...

Monash University, Australia. ...

Imperial College London, United Kingdom. ...

The University of Tokyo, Japan.

As of September 2020, the value of pharmaceutical products imported from India was approximately 235 billion Indian rupees.

Import Value of Indian Pharmaceutical Products, 2010-2020

As of September 2020, the value of pharmaceutical products imported from India was approximately 235 billion Indian rupees. This is a decrease from the previous year's import value (444.4 billion rupees).

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Jardiance (Empagliflozin Tablets): Uses, Dosage, Side Effects ...

What is Jardiance?

Jardiance (empagliflozin) is an oral diabetes medication that helps control blood sugar levels. Empagliflozin's role is to help the kidneys clear glucose from the blood. Jardiance combined with diet and exercise can improve blood sugar control in adults with type 2 diabetes.

Jardiance (empagliflozin) is an inhibitor of sodium-glucose cotransporter 2 (SGLT2) and can be used as an aid to diet and exercise to improve blood sugar control in adults with type 2 diabetes. Jardiance can also reduce the risk of cardiovascular death in adults with type 2 diabetes and cardiovascular disease.

What are the side effects of cleverness?

Common side effects of Jardiance include:

• Dehydration
• dizziness,
• Dizziness,
• weakness,
• Yeast infections,
• Hypoglycemia,
• nausea,
• Upper respiratory tract infection,
• High cholesterol,
• Joint pain,
• Increased urination,
• Urinary tract infection
• thirsty
• Low blood pressure (hypotension).

Description

JARDIANCE tablets contain Eglitazone, an oral active inhibitor of sodium-glucose cotransporter 2 (SGLT2).

The chemical name of Ipagliflozin is D-glucitol, 1,5-anhydro-1-C- [4-chloro-3-[[4-[[((3S) -tetrahydro-3furyl] oxy] Phenyl] methyl] phenyl]-, (1S).

Indications

JARDIANCE is indicated:

As an aid to diet and exercise to improve blood sugar control in adults with type 2 diabetes,

To reduce the risk of cardiovascular death in adults with type 2 diabetes and diagnosed cardiovascular disease.

Use restrictions

JARDIANCE is not recommended for patients with type 1 diabetes or diabetic ketoacidosis.

Dosage and administration

Recommended dose

The recommended JARDIANCE dosage is once a day, once a day, 10 mg each time, with or without food. In patients who are tolerant to JARDIANCE, the dose can be increased to 25 mg.

For patients with physical exhaustion, it is recommended to correct this situation before starting JARDIANCE

Formulations and advantages

The JARDIANCE tablet can be used as:

• 10 mg light yellow, round, biconvex and cut-edge film-coated tablets with "S 10" engraved on one side and the Boehringer Ingelheim logo on the other side.
• 25 mg light yellow, oval, biconvex, film-coated tablet with "S 25" engraved on one side and Boehringer Ingelheim logo on the other.

Storage and handling

The strength of JARDIANCE tablets is 10 mg and 25 mg, as follows:

10 mg tablets: light yellow, round, biconvex and beveled, film-coated tablets with "S 10" recessed on one side and the Boehringer Ingelheim logo on the other side.

Side effect

The following and other adverse reactions are described below and elsewhere on the label:

• Hypotension 
• Ketoacidosis 
• Acute kidney injury and kidney function damage
• Uremic and pyelonephritis
• Hypoglycemia is used with insulin and insulin secretagogues 
• Perineal necrotizing fasciitis
• Genital fungal infections
• Allergic reactions
• Increased low-density lipoprotein cholesterol (LDL-C)

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Glyxambi Oral : Uses, Side Effects, Interactions, Pictures ...

What is Glyxambi? 

Glyxambi contains a combination of Empagliflozin and linagliptin. Empagliflozin and linagliptin are oral diabetes drugs that can help control blood sugar levels. Empagliflozin's role is to help the kidneys clear glucose from the blood.

GLYXAMBI is a prescription drug that contains 2 types of diabetes drugs, ipagliflozin (JARDIANCE) and liragliptin (TRADJENTA). GLYXAMBI can be used together with diet and exercise to reduce blood glucose in adults with type 2 diabetes (TRADJENTA) when using JARDIANCE and liragliptin (2) at the same time.

GLYXAMBI is not suitable for patients with type 1 diabetes.

GLYXAMBI is not suitable for people with diabetic ketoacidosis (increased ketones in blood or urine). If you have had pancreatitis in the past, you do n’t know if you are more likely to get pancreatitis when taking GLYXAMBI.

Uses

The drug is a combination of 2 drugs: ipagliflozin and liragliptin. It is used in conjunction with an appropriate diet and exercise program to control hyperglycemia in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes can also reduce the risk of heart attack or stroke. The role of Empagliflozin is to increase the removal of sugar by the kidneys. Ligliptin works by adding a natural substance called incretin. Enterostatin helps control blood sugar by increasing the release of insulin, especially after a meal. They also reduce the sugar produced by the liver.

How to use Glyxambi ?

Before you start taking this medicine, and every time you add it, please read the "Guide to Medicine" provided by the pharmacist. If you have any questions, please consult your doctor or pharmacist.

According to the doctor's instructions, this medicine is usually taken orally once a morning or without food. The dosage depends on your medical condition and response to treatment.

The fact of Glyxambi (empagliflozin)?

Drug Name: Glyxambi

Common name: Ipagliflozin

Approval date: August 2014

Company name: Boehringer Ingelheim International Co., Ltd.

Available forms and strengths: Tablets: 10 mg empagliflozin / 5 mg ligagliptin and 25 mg empagliflozin / 5 mg ligagliptin

What are the indications and usage?

When properly treated with Iglitazone and Ligliptin, GLYXAMBI tablets can be used as an aid to diet and exercise to improve blood sugar control in adults with type 2 diabetes.

Use restrictions

GLYXAMBI is not recommended for the treatment of patients with type 1 diabetes or diabetic ketoacidosis.

GLYXAMBI has not been studied in patients with a history of pancreatitis. It is not clear whether patients with a history of pancreatitis have an increased risk of pancreatitis when using GLYXAMB

Side Effect

May often urinate, dizziness or dizziness. If these effects persist or worsen, please inform your doctor or pharmacist immediately.

To reduce the risk of dizziness and dizziness, slowly stand up when lifting from a sitting or lying position.

Remember, your doctor prescribes this medicine because he or she thinks the benefits to you outweigh the risk of side effects. Many people who use this medicine do not have serious side effects.

Precaution

Before taking this medicine, please tell your doctor or pharmacist if you are allergic to ipagliptin or ritagliptin; or you have other allergic reactions. This product may contain inactive ingredients that may cause allergic reactions or other problems. Contact your pharmacist for more details.

Overdose

If someone overdoses and has severe symptoms, such as fainting or difficulty breathing, please call 911. Otherwise, please call the poison control center immediately. US residents can call 1-800-222-1222 and the local poison control center. Canadian residents can call the Provincial Poison Control Center.

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Hepcinat 400 mg Tablet - Uses, Dosage, Side Effects, Price ...

Discription

Hepcinat 400 mg Tablet is an antiviral drug used to treat chronic hepatitis C infection. It is also used in patients with liver cancer and hepatitis C infection planning to undergo liver transplantation. This drug minimizes the chance of infection recurring after transplantation. Hepcinat 400 mg Tablet is not recommended for patients with a known history of hepatitis B infection.

What is the purpose of Hepcinat (Sofosbuvir)?

Hepcinat, considered to be a real breakthrough in the treatment of chronic hepatitis C, has recently emerged in the world pharmaceutical market. Sofosbuvir can now replace interferon, which is widely known for causing certain adverse reactions and has many contraindications. Currently, it has been approved for use in 120 countries around the world. Sofosbuvir can be used to treat patients with cirrhosis and HIV.

Side Effects

Major & minor side effects for Hepcinat 400 mg Tablet

• chill
• Mouth sores or leukoplakia
• lumbago
• headache
• rash
• irritability
• diarrhea
• nausea
• Loss of appetite
• Muscle pain and cramps

Uses of Hepcinat 400 mg tablets

What are the rules?

• Chronic hepatitis C

          Hepcinat 400 mg tablets are used to treat chronic hepatitis C virus infection to prevent the                   growth and spread of the virus in the body.

• Hepatocellular carcinoma and liver transplantation

          The drug is used to plan liver transplantation to prevent patients with hepatocellular carcinoma            and hepatitis C from recurring infection.


Dosage and administration

Each film-coated tablet of Hepcinat (Sofosbuvir) contains 400 mg of the main ingredient. The dosage table must be individualized by the physician responsible for the treatment and will vary according to the genotype of the virus being treated. Adult patients are usually instructed by their doctor to take 1 tablet a day, either with or without food.

The doctor may order patients with GT1 or GT4 (genotype 1 or 4) to take it with ribavirin and pegylated interferon alpha for 12 weeks. In contrast, GT2 (genotype 2) usually requires 12 weeks of treatment and is taken with ribavirin. GT3 (genotype 3) requires 24 weeks of treatment with ribavirin. Patients can only be taken according to the instructions provided by the physician responsible for treatment

Precaution

Patients receiving Hepcinat medication for Hepatitis C need to see a doctor or hospital regularly so that a routine blood test can be performed. The frequency of these tests will be determined by your doctor.

Unborn babies associated with this drug are at risk of birth defects or other serious injuries, and pregnant women should never take them. During treatment and for at least 6 months after treatment, at least 2 effective non-hormonal barrier methods of contraception should always be used.

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Melphalan Oral : Uses, Side Effects, Interactions

Why should I prescribe this medicine?

Melphalan is used to treat multiple myeloma (a type of bone marrow cancer). Melphalan is also used to treat certain types of ovarian cancer (cancer starts with the female reproductive organs that form eggs). Melphalan belongs to a class of drugs called alkylating agents. It works by preventing or slowing the growth of cancer cells in the body.

How to use this medicine?

Melphalan can be taken orally as a tablet. It is usually taken once per abdomen. The length of treatment depends on the type of medicine you are taking, how well your body responds to the medicine, and the type of cancer you have. Take melphalan at about the same time every day. Follow the instructions on the prescription label carefully and ask the doctor or pharmacist to explain any parts you do not understand. Take Melphalan exactly as directed. Do not take it more or less, and do not take excessive doses.

Before taking melphalan,

• Tell your doctor and pharmacist if you are allergic to melphalan, any other medicines or any ingredient in melphalan tablets. Ask your pharmacist for a list of ingredients.
• Tell your doctor and pharmacist what other prescription and over-the-counter medicines, vitamins, nutritional supplements, and herbs you are taking or plan to take. Be sure to mention any of the following: Carmustine (BICNU, BCNU), Cimetidine (Tagamet), Cisplatin (Platinol AQ), Cyclosporine (Sandimmune, Gengraf, Neoral) or Interferon alpha (Intron A, Infergen, Alferon N).
• Tell your doctor if you have taken melphalan before, but your cancer has not responded to the drug. Your doctor may tell you not to take melphalan.
• Tell your doctor if you have recently received radiation therapy or other chemotherapy, or if you have or have had kidney disease.
• Do not get any vaccines without talking to your doctor.

What special dietary guidelines should I follow?

Unless your doctor instructs otherwise, please continue to eat normally.

What if I forget to take the medicine?

Melphalan may cause side effects. Tell your doctor if these symptoms are serious or not gone:

• nausea
• Vomiting
• Loss of appetite or weight loss
• Mouth and sore throat
• Missed period (girls and women)
• Pain in joints, muscles or back

Some side effects can be serious. If you experience any of the above symptoms or the symptoms listed in the "Important Warning" section, please call your doctor immediately:

What should I know about storage and disposal of this medicine?

Keep this medicine in the container it comes in, tightly closed, and out of reach of children. Store it in the refrigerator away from light.

Symptoms of overdose may include the following:

• Vomiting
• diarrhea
• Mouth and sore throat
• Black, tar or bloody stools
• Bloody vomit or coffee-like vomit
• Unusual bruising or bleeding
• Sore throat, cough, fever or other signs of infection

What other information should I know?

Don't let anyone take your medicine. Ask your pharmacist any questions about supplementing prescriptions.

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Learn About Your Treatment With VELCADE (bortezomib)

Bortezomib is an anti-cancer drug used to treat multiple myeloma and mantle cell lymphoma. This includes those with multiple myeloma who have received treatment or have never received treatment. It is usually used with other drugs. It is given by injection.

Uses

The drug is a cancer chemotherapy drug used to treat certain types of tumors. It blocks certain proteins, thereby helping to slow the growth and spread of cancer.

How to use:

This medicine is given by a medical professional by intravenous injection or under the skin. If you use this medicine under the skin, make sure to change the injection site every time to reduce the damage under the skin. The dosage depends on your size, medical condition and response to treatment. When using this medication, be sure to drink plenty of fluids to prevent dehydration.

Side effect:

Dizziness, dizziness, nausea, vomiting, loss of appetite, diarrhea, constipation, fatigue, weakness, blurred vision, or pain / redness at the injection site may occur.
If these effects persist or worsen, please notify your doctor or pharmacist immediately. Remember, your doctor has prescribed this medicine because he or she judges that the benefits to you outweigh the risk of side effects

Many people who use this medicine do not have serious side effects. This medicine will reduce your body's ability to fight infections. If you find any signs of infection such as fever, chills or sore throat, please notify the doctor immediately.

Precaution

Before using this medicine, tell your doctor or pharmacist if you are allergic to it; or you have other allergic reactions. This product may contain inactive ingredients that may cause allergic reactions or other problems. Please contact your pharmacist for more detailed information. Before using this medicine, please tell your doctor or pharmacist your medical history, especially: neurosensory problems, heart disease, low blood pressure, fluid loss, diabetes, liver disease, severe kidney disease, certain viral infections.

Medicine interactions:

Drug interactions may change the way drugs work or increase the risk of serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription / over-the-counter and herbal products) and share them with your doctor and pharmacist.

Overdose

If you suspect an overdose, please immediately contact a poison control center or emergency room and the local poison control center. Canadian residents can call the Provincial Poison Control Center. Symptoms of overdose may include: fainting or persistent fever.

Missed dose

For maximum benefit, it is important to receive each predetermined dose of medication as directed. If you miss a dose, please contact your doctor or pharmacist immediately to establish a new dosing schedule.

Storage

Not applicable. The medicine is provided in the clinic and will not be stored at home. Medical Tip: Your situation may cause complications in a medical emergency.

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