Mekinist, How to give Mekinist, Mekinist is used to

Mekinist

Common name: Trimetinib

Mekinist is the trade name of the generic chemotherapy drug trametinib. named patient medicines In some cases, healthcare professionals may use the generic name melmetinib when referring to the trade name Mekinist.

Type of drug: Mekinist is a targeted therapy. It is an oral MEK inhibitor-(For more details, see "How the drug works" below.)

Mekinist is used to:

It is used to treat unresectable or metastatic melanoma caused by BRAF gene defects. named patient basis As shown by the FDA approved test, cancer must be (BRAF) positive.

 It is used in combination with Tafinlar® to treat metastatic non-small cell lung cancer (NSCLC). As shown by the FDA approved test, cancer must be BRAF positive.

Note: If a drug has been approved for one use, doctors may choose to use this drug for other problems if they think it may be helpful.

How to give Mekinist:

•     Mekinist is an oral medicine, once a day. At least 1 hour before a meal or 2 hours after a meal.
•     Take Mekinist in strict accordance with regulations.
•     Swallow Mekinist tablets whole. Do not crush or dissolve tablets.
•     Unless your healthcare provider tells you, do not change the dosage or stop Mekinist.
•     If you miss the dose, please remember as soon as possible. If it has been more than 12 hours since the missed dose, skip the missed dose and return to your normal time.
•     Do not take more than 1 dose of Mekinist at a time. If you take too much, call your health care provider immediately.
•     Store Mekinist in a refrigerator between 36°F and 46°F, not in the freezer.
•     Place the tablets in the bottle that comes in, and do not move them to the pill holder.
•     Store in the original container. Do not remove moisture-proof packaging. Avoid light.
•     Keep medicines away from children and pets.
•     The amount of Mekinist you will receive depends on many factors, your overall health condition or other health problems, and the type of cancer or condition being treated. The current recommendation is to take one tablet a day. Higher doses do not always produce better response and may lead to increased toxicity. Your doctor will determine your dosage and schedule.

Jardiance Storage, side effects of Jardiance?, What to do if you take an overdose, safety

 Jardiance storage

Jardiance should be stored at room temperature, away from moisture and heat, and kept in its original container. You must make sure that it is out of sight of children.
What are the side effects of Jardiance?

Side effects of Jardiance include:

    Problems with urination-frequent urination or very little urination
    Increased likelihood of urinary tract infection
    Signs of genital infection-such as pain, itching or rash
    Hypoglycemia-if taken with drugs that lower blood sugar levels
    Elevated cholesterol
    Feeling tired or dizzy

Please note that the above list is not exhaustive. imported medicines in India. You should refer to the patient information manual in the medication for a complete list of side effects.
What to do if you take too much medicine

If you overdose Jardiance, please contact your health team immediately for advice.
Long-term security

There are questions about whether SGLT2 inhibitors have harmful long-term effects on the kidneys. Invokana and Jardiance belong to the same drug category and are related to the decline of eGFR, which is a marker used to measure kidney function.

According to a report from the European Medicines Agency, the most common adverse reaction to Jardiance is hypoglycemia-this occurs when used with sulfonylurea or insulin.

The American Association of Clinical Endocrinologists will investigate whether SGLT2 inhibitors are responsible for the high incidence of diabetic ketoacidosis. Named Patient Program India, They plan to conduct this assessment in the fall of 2015.

Who is Jardiance Suitable for, Who Should not take, How Should be Taken

Who is Jardiance suitable for?

The National Institute of Clinical Excellence (NICE) recommends Jardiance to treat type 2 diabetes in the following situations:

    When diet and exercise do not provide adequate blood sugar control
    When metformin is inappropriate due to patient intolerance

If the patient has a significant risk of hypoglycemia or cannot take sulfonylurea drugs, it is also recommended to use Jardiance with metformin. named patient medicines. It can also be combined with metformin or sulfonylurea.

Who should not take Jardiance?

You should not take Jardiance if you have the following conditions:

    Type 1 diabetes
    Severe kidney problems

Before taking Jardiance, you should tell your doctor:

    Have kidney problems
    Are pregnant or plan to become pregnant
    Breastfeeding or planning to breastfeed
    Have liver disease
    Low blood pressure
    Taking antihypertensive drugs
    High cholesterol content
    Have a history of urinary tract infections
    65 years old
    Low salt diet

How should Jardiance be taken?

Jardiance is administered orally and is usually taken once a morning-it can be taken with or without food.

The drug was initially prescribed for a 10 mg dose, with a maximum dose of 25 mg. Pharmaceutical Consulting Company Although your doctor may change the dosage to ensure the best results, you should not take Jardiance at the recommended larger or smaller dosage.

If you miss a dose, you should take it as soon as you remember. However, you should not take an extra dose to make up for the medicine you missed. If the next scheduled dose is almost the same, you should skip the previously missed dose.

About Jardiance(Empagliflozin) , How jardiance helps type2 Diabetes, Mechanism

Jardiance is a once-daily oral medication used to control blood sugar levels in patients with type 2 diabetes.

This is achieved by helping the kidneys remove glucose from the blood through urine.

Jardiance is not used to lose weight or control blood pressure, but it can help you at the same time. pharma consulting companies. It is used as part of a treatment plan, which may include exercise, diet and special medical care.

The drug was approved by the European Commission in May 2014. As a relatively new drug, its long-term effects within a few years are unclear.

About Jardiance

    Product Name: Jardiance
    Common name: Empagliflozin
    Drug category: SGLT2 inhibitor
    Manufacturers: Boehringer Ingelheim and Eli Lilly and Diabetes

How Jardiance helps type 2 diabetes

By expelling excess glucose from the urine, Jardinance helps improve blood sugar control in patients with type 2 diabetes. named Patient supply This can lead to improved HbA1c levels, thereby reducing the risk of diabetes-related complications.

Since calories in glucose are also excreted from the body, the use of Jardiance may cause weight loss. Since type 2 diabetes is closely related to body weight-about 90% of newly diagnosed type 2 diabetes exceeds its ideal body weight-this helps maintain healthy body weight.

Jardiance is used as part of the treatment plan, in addition to Jardiance treatment, it is also important to maintain other aspects (such as physical exercise).

Mechanism of action

Empagliflozin is an SGLT2 inhibitor, a drug class that helps prevent sodium and glucose transporters that are filtered from the blood as the kidney is reabsorbed back into the blood.

Empagliflozin allows large amounts of sugar to be removed by urination. SGLT2 protein accounts for 90% of glucose reabsorbed into the blood.