HEPCINAT SOFOSBUVIR TABLETS 400MG INTRODUCTION AND BENIFITS

 Hepcinat Tablet is an antiviral drug. It is used with other drugs to treat chronic hepatitis C virus (HCV) infection. It works by reducing the load of the hepatitis C virus in the body and removing the virus from the blood over a period of time.

Hepcinat Tablet should be taken in accordance with the doctor's recommendations for the dosage and duration. Even if you feel better, do not skip any doses and complete the entire course of treatment. It should be taken with food, preferably at a fixed time. If you miss a dose, take it as soon as possible. However, if it’s almost time for your next medication, skip the missed medication and go back to the regular schedule. Do not double the dose.

Compared with other similar drugs, it has fewer side effects, such as fatigue, headache, nausea, insomnia (difficulty sleeping) and anemia (low red blood cell count). If these side effects persist for a long time, please inform your doctor. If you are pregnant, planning to become pregnant or breastfeeding, please consult your doctor.

Benefits of Hepcinat tablets

In chronic hepatitis C virus (HCV) infection

Hepcinat Tablet works by preventing the HCV virus from multiplying in your body. It helps control infections and makes the immune system work better. This reduces your chances of complications and improves your quality of life. This drug is always combined with other antiretroviral drugs. It is not a cure and should not be used to prevent HCV infection. It is important to take the medicine according to the prescription recommended by your doctor. Taking all doses at the right time and in the right amount can greatly increase the effectiveness of the medicine.

Lenalidomide Capsule Uses

 Lenalidomide is used to treat various types of cancer. It works by slowing down or stopping the growth of cancer cells. It can also be used to treat anemia of certain blood/bone marrow diseases (myelodysplastic syndrome-MDS). Lenalidomide can reduce the need for blood transfusions. Lenalidomide is not recommended to treat certain types of cancer (chronic lymphocytic leukemia) because it increases the risk of serious heart-related side effects and death. If you have this cancer, talk to your doctor about the risks of using this medicine.

How to use lenalidomide capsules

Please read the Medication Guide provided by your pharmacist before starting lenalidomide and every time you supplement. If you have any questions, please consult your doctor or pharmacist.

Follow your doctor's instructions to take this medication by mouth, with or without food, usually once a day. Swallow the whole medicine with water. For the treatment of certain diseases, you may be instructed to take the drug in cycles (once a day for 21 days, then stop the drug for 7 days). The dosage depends on your medical condition, response to treatment, and laboratory test results. Make sure to follow your doctor's instructions carefully.

Do not open, chew or break the capsule, and do not over-process the capsule. If any powder in the capsule gets on the skin, wash the area with soap and water.

Because the drug can be absorbed through the skin and lungs, and may harm an unborn baby, pregnant women or women who may become pregnant should not use the drug or inhale dust from broken capsules. Everyone should wash their hands thoroughly after using the drug.

Use this medication regularly to get the most benefit from it. Remember to take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

BORTEZOMIB FOR INJECTION BORTENAT LYOPHILIZED PRECAUTIONS

 Before using this medicine, tell your doctor or pharmacist if you are allergic to it; or if you have other allergic reactions. This product may contain inactive ingredients (such as boron, mannitol), which may cause allergic reactions or other problems. Contact your pharmacist for more details.

Before using this medication, please tell your doctor or pharmacist your medical history, especially the following diseases: nerve problems (such as peripheral neuropathy), liver disease, kidney disease, excessive body water (dehydration), heart disease ( Such as heart failure), bleeding/blood diseases, current/recent infections, diabetes.

This medicine may make you dizzy. Alcohol or marijuana (marijuana) can make you dizzy. Do not drive, use machinery or do anything that requires attention before operating safely. Limit alcoholic beverages. If you use marijuana (marijuana), consult your doctor.

Before having surgery, please inform your doctor or dentist of all the products you use (including prescription drugs, over-the-counter drugs and herbal products).

Bortezomib can make you more susceptible to infection or make your current infection worse. Avoid contact with infected people who may spread to others (such as chickenpox, measles, flu). If you are infected or for more details, please consult your doctor.

Do not get immunizations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To reduce the chance of cuts, abrasions or injuries, use sharp objects such as razors and nail clippers with caution, and avoid activities such as contact sports.

BORTEZOMIB FOR INJECTION BORTENAT LYOPHILIZED USES AND SIDE EFFECTS

 This medication is given by a healthcare professional by intravenous injection or under the skin. If you receive this medication under the skin, make sure to change the injection site every time to reduce the damage under the skin. The dosage depends on your size, medical condition, laboratory tests, and response to treatment.

To prevent dehydration, be sure to drink plenty of fluids when using this medication. If you have any questions, please consult your doctor or pharmacist.

Dizziness, dizziness, nausea, vomiting, loss of appetite, diarrhea, constipation, fatigue, weakness, or pain/redness at the injection site may occur. Nausea, vomiting and diarrhea can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea, vomiting, and diarrhea. If these effects persist or worsen, please inform your doctor or pharmacist immediately.

To reduce the risk of dizziness and dizziness, get up slowly when lifting from a sitting or lying position.

People who use this drug may have serious side effects. However, your doctor prescribed this medicine because he or she judged that the benefits to you outweigh the risks of side effects. The doctor's careful monitoring may reduce your risk.

Bortezomib sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). To reduce the risk, your doctor may add medicine and tell you to drink plenty of water. Tell your doctor immediately if you have the following symptoms: lower back/side pain (back pain), signs of kidney problems (such as painful urination, pink/bloody urine, changes in urine output), muscle cramps/weakness.

If you have any serious side effects, please tell your doctor immediately, including: tingling/numbness/pain/arm/leg fever, syncope, severe headache, mental/mood changes (such as confusion), severe abdominal/abdominal pain, signs of liver disease (Such as yellow eyes/skin, yellow urine), heart failure symptoms (such as shortness of breath, ankle/foot swelling, abnormal fatigue, abnormal weight/sudden increase).

If you have any very serious side effects, seek medical help immediately, including: chest pain, difficulty breathing, vision changes, seizures, weakness on one side of the body, and difficulty speaking.

This medication can reduce blood cells, which can lead to anemia, reduce the body's ability to fight infection or cause easy bruising/bleeding. Tell your doctor immediately if you experience any of the following symptoms: easy bleeding/bruising, black/tar-like stools, vomit that looks like coffee grounds, signs of infection (such as persistent sore throat, fever, chills), abnormal Tired, pale skin.

Very severe allergic reactions to this drug are rare. However, if you notice any symptoms of a severe allergic reaction, including skin rash, itching/swelling (especially face/tongue/throat), severe dizziness, and difficulty breathing, please seek medical help immediately.

Bortezomib usually causes a rash, which is usually not serious. However, you may not be able to tell it apart from the rare rash, which may be a sign of a serious reaction. If a rash occurs, seek medical help immediately.

Melphalan Tablet Side Effects

 There may be nausea, vomiting, diarrhea, lip/mouth sores and loss of appetite. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating a few small meals, not eating before treatment, or restricting the amount of activity may help reduce some effects. If these effects persist or worsen, please inform your doctor or pharmacist immediately.

Temporary hair loss may occur. After the treatment, the hair returned to normal growth.

People who use this drug may have serious side effects. However, your doctor prescribed this medicine because he or she judged that the benefits to you outweigh the risks of side effects. The doctor's careful monitoring may reduce your risk.

If you have any serious side effects, please tell your doctor immediately, such as: shortness of breath, menstruation stopped (in women), symptoms of liver disease (such as stomach/abdominal pain, yellow eyes/skin, dark urine).

Very severe allergic reactions to this drug are rare. However, if you notice any symptoms of a severe allergic reaction, such as rash, itching/swelling (especially face/tongue/throat), severe dizziness, and difficulty breathing, please seek medical help immediately.

This is not a complete list of possible side effects. If you notice other effects not listed above, please contact your doctor or pharmacist

ENTYVIO Side Effects

 There may be nausea, headache, flu/cold symptoms or tiredness. If these effects persist or worsen, tell your doctor or pharmacist immediately.

Remember, your doctor prescribes this medicine because he or she believes that the benefits to you outweigh the risks of side effects. Many people who use this drug do not have serious side effects.

If you have any serious side effects, please tell your doctor immediately, including: mouth/sore throat, arm/leg pain, symptoms of liver damage (such as persistent nausea/vomiting, loss of appetite, stomach/abdominal pain, yellow eyes) /Skin, dark urine).

This medication may reduce your ability to fight infections. This may make you more likely to have a serious (very fatal) infection, or make your infection more serious. If you have any signs of infection (eg fever, chills, persistent sore throat, cough), please tell your doctor immediately.

This medication may increase your risk of a rare but very serious (possibly fatal) brain infection (progressive multifocal leukoencephalopathy-PML). If you have any of the following side effects, seek medical help immediately: clumsiness, loss of coordination/balance, weakness, sudden changes in thinking (such as confusion, inattention, memory loss), difficulty speaking/walking, seizures, changes in vision.

Very severe allergic reactions to this drug are rare. However, if you notice any symptoms of a severe allergic reaction, including rash, itching/swelling (especially face/tongue/throat), severe dizziness, and difficulty breathing, please seek medical help immediately.

This is not a complete list of possible side effects. If you notice other effects not listed above, please contact your doctor or pharmacist.

DEFITELIO DOSAGE AND ADMINISTRATION

 The recommended dosage of DEFITELIO for adult and pediatric patients is 6.25 mg/kg every 6 hours given as a 2- hour intravenous infusion. The dose should be based on patient's baseline body weight, defined as the patient's weight prior to the preparative regimen for HSCT.

Administer DEFITELIO for a minimum of 21 days. If after 21 days signs and symptoms of hepatic VOD have not resolved, continue DEFITELIO until resolution of VOD or up to a maximum of 60 days.
Administration Instructions

    DEFITELIO must be diluted prior to infusion [see Preparation Instructions].
    Prior to administration of DEFITELIO, confirm that the patient is not experiencing clinically significant bleeding and is hemodynamically stable on no more than one vasopressor [see WARNINGS AND PRECAUTIONS].

    Administer DEFITELIO by constant intravenous infusion over a 2-hour period.
    Administer the diluted DEFITELIO solution using an infusion set equipped with a 0.2 micron in-line filter. Flush the intravenous administration line (peripheral or central) with 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP immediately before and after administration.
    Do not co-administer DEFITELIO and other intravenous drugs concurrently within the same intravenous line.

Preparation Instructions

Dilute DEFITELIO in 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP to a concentration of 4 mg/mL to 20 mg/mL. Administer the diluted solution over 2 hours.

Vials contain no antimicrobial preservatives and are intended for a single-patient-use only. Partially used vials should be discarded. Use the diluted DEFITELIO solution within 4 hours if stored at room temperature or within 24 hours if stored under refrigeration. Up to four doses of DEFITELIO solution may be prepared at one time, if refrigerated.
Preparation Instructions

    Determine the dose (mg) and number of vials of DEFITELIO based on the individual patient's baseline weight (weight prior to the preparative regimen for HSCT).
    Calculate the volume of DEFITELIO needed, withdraw this amount from the vial(s) and add it to the infusion bag containing 0.9% Sodium Chloride Injection or 5% Dextrose Injection for each dose to make a final concentration of 4 mg/mL to 20 mg/mL.
    Gently mix the solution for infusion.
    Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Only clear solutions without visible particles should be used. Depending on the type and amount of diluent, the color of the diluted solution may vary from colorless to light yellow.

DEFITELIO

 Defibrotide sodium is an oligonucleotide mixture with profibrinolytic properties. The chemical name of defibrotide sodium is polydeoxyribonucleotide, sodium salt. Defibrotide sodium is a polydisperse mixture of predominantly single-stranded (ss) polydeoxyribonucleotide sodium salts derived from porcine intestinal tissue having a mean weighted molecular weight of 13-20 kDa, and a potency of 27-39 and 28-38 biological units per mg as determined by two separate assays measuring the release of a product formed by contact between defibrotide sodium, plasmin and a plasmin substrate. The primary structure of defibrotide sodium is shown below.

DEFITELIO (defibrotide sodium) injection is a clear, light yellow to brown, sterile, preservative-free solution in a single-patient-use vial for intravenous use. Each milliliter of the injection contains 80 mg of defibrotide sodium and 10 mg of Sodium Citrate, USP, in Water for Injection, USP. Hydrochloric Acid, NF, and/or Sodium Hydroxide, NF, may have been used to adjust pH to 6.8-7.8.

INDICATIONS

DEFITELIO is indicated for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT).

Main Types of ASL

 
What Are the Main Types?

There are two types of ALS:

Sporadic ALS is the most common form. It affects up to 95% of people with the disease. Sporadic means it happens sometimes without a clear cause.

    Familial ALS (FALS) runs in families. About 5% to 10% of people with ALS have this type. FALS is caused by changes to a gene. Parents pass the faulty gene to their children. If one parent has the gene for ALS, each of their children will have a 50% chance of getting the gene and having the disease.

What Causes ALS?

Researchers still don't know exactly what causes motor neurons to die with ALS. Gene changes, or mutations, are behind 5% to 10% of ALS cases. More than 12 different gene changes have been linked to ALS.

One change is to a gene that makes a protein called SOD1. This protein may be toxic to motor neurons. Other gene changes in ALS might also damage motor neurons.

Environment could also play a role in ALS. Scientists are studying whether people who come into contact with certain chemicals or germs are more likely to get the disease. For example, people who served in the military during the 1991 Gulf War have gotten ALS at higher rates than usual.

Zydelig Side effects

Side Effects

See also Warning section.

Diarrhea, headache, heartburn, mouth/throat sores, and trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacetical consulting company.

People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, swelling hands/ankles/feet, sudden vision changes.

Idelalisib can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Therefore, get medical help right away if you develop any rash.

This medication can weaken the immune system/increase the risk of infection, including a rare but very serious (possibly fatal) brain infection (progressive multifocal leukoencephalopathy-PML). Get medical help right away if you have any of these side effects: clumsiness, loss of coordination/balance, weakness, sudden change in your thinking (such as confusion, difficulty concentrating, memory loss), difficulty talking/walking, seizure.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Side effects of Elprase

 Common side effects of Elaprase include: abscess, chest wall pain, dyspepsia, infusion related reaction, pruritic rash, pruritus, urticaria, and visual disturbance. See below for a comprehensive list of adverse effects.

 

Side effects requiring immediate medical attention

Along with its needed effects, idursulfase (the active ingredient contained in Elaprase) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking idursulfase:

More common

• Bone or muscle pain
• chest pain
• chills
• cough
• fast, pounding, or irregular heartbeat or pulse
• feeling of warmth
• fever
• headache
• hives or welts
• itching
• rash
• redness of the face, neck, arms, and occasionally, upper chest
• redness of the skin
• sneezing
• sore throat
• tightness in the chest
• unusual tiredness or weakness

Less common

• Blurred vision
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• sweating

Incidence not known

• Difficulty with swallowing
• dilated neck veins
• extreme fatigue
• heart stops
• irregular breathing
• no breathing
• no pulse or blood pressure
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• unconscious
• weight gain

Side effects not requiring immediate medical attention

Some side effects of idursulfase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Change in hearing
• diarrhea
• ear drainage
• earache or pain in the ear

Less common

• Nausea
• vomiting

Lonsurf

 Generic Name: Trifluridine/Tipiricil

Trifluridine/tipiricil is the generic name for the trade name drug, Lonsurf. In some cases, health care professionals may use the trade name, Lonsurf, when referring to the generic drug name, trifluridine/tipiricil.

Drug Type: Trifluridine/tipiricil is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. pharma consulting companies,This medication is classified as an antimetabolite/pyrimidine analog; antimetabolite/thymidine phosphorylase inhibitor. (For more detail, see "How Trifluridine/tipiricil Works" below).

What Trifluridine/tipiricil Is Used For:

• Trifluridine/tipiricil is used to treat metastatic colorectal cancer in patients who have previously been treated with fluoropyrimidine, oxaliplatin, and irinotecan based chemotherapy, an anti-VEGF biological therapy, and an anti-EGFR therapy (if RAS wild type).
• To treat metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma previously treated with at least two prior lines of chemotherapy that included fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu-targeted therapy.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Trifluridine/tipiricil Is Given:

• Trifluridine/tipiricil is a tablet that is taken by mouth.
• Take twice a day within one hour of eating your morning and evening meals.
• Take with a glass of water.
• The tablets come in two strengths and you may need to take a combination of the two strengths to get to your specific dose. Follow your instructions carefully.
• Trifluridine/tipiricil is usually taken twice a day on days 1 to 5, and days 8 to 12 of a 28 day cycle.

The amount of trifluridine/tipiricil that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

Advance medicinal treatment of Neurological disorder

Disorders occurring in the central and peripheral nervous system comprise of neurological disorders. These disorders include Alzheimer disease, dementias, cerebrovascular disease, Parkinson’s disease, and traumatic disorder. It is assessed that more than 6 million people die because of stroke each year and an astonishing figure of 80% is that from developing and poor countries.

Lack of proper medications and knowledge, in regards, to neurological disorder causes increasing mortality rate every year. Thus, FDA has approved some widely accepted drugs termed to be a named patient medicine, as the medicines are frequently not available in the underdeveloped and developing countries.

Xadago, an orally administered medicine for the patients suffering from Parkinson’s disease is recommended from 100 mg to 50 mg as per the condition of the patient. It inhibits MAO-B activity after hindering the catabolism of dopamine and thus acting as a mechanical obstruct for Parkinson disease.

Also, Banzel, a triazole derivative is an indicative treatment drug for Seizures allied with Lennox Gastaut syndrome, which is common among children above 4 years and then into adults. The prescribed initial dose per day ranges from 400 mg to 800 mg and a maximum dose of 3200 mg per day. Although the exact mechanism of Banzel is unknown, yet the rufinamide modulates the activity of sodium channels which, in turn, slows down the seizures and its aligned symptoms.

The pharmaceutical consulting services allow the neurology department and its named patient program to export these medicines worldwide, with all its approvals and advancement to cure the fatal diseases like Parkinson and Lennox Gastaut syndrome.

Langsurf

Langsurf

Generic name: Trifluoropyridine/Tbilisi

Trifluridine/empirical is the generic name of the trade name drug Lonsurf. In some cases, healthcare professionals may use the trade name Lonsurf when referring to the generic drug name trifluoropyridine/tipixetate.

Type of drug: Trifluridine/tipiricil is an anti-cancer ("antitumor drug" or "cytotoxic") chemotherapy drug. pharma consulting companies The drug is classified as an antimetabolite/pyrimidine analogue; antimetabolite/thymidine phosphorylase inhibitor. (For more detailed information, please refer to "The working principle of trifluoropyridine/tips late" below).
Trifluoropyridine/Tibisidate is used for:

 Trifluridine / empirical can be used to treat patients who have previously received fluoropyrimidine, oxaliplatin and irinotecan, anti-VEGF biological therapy and anti-EGFR therapy (if RAS wild-type), for the treatment of metastatic colorectal cancer.

    In order to treat metastatic gastric cancer or gastroesophageal junction (GEJ) adenocarcinoma, he has received at least two previous chemotherapy, including fluoropyrimidine, platinum, taxane or irinotecan, and appropriate HER2/neu targeted therapy.

Note: If one use of a drug has been approved, the doctor may choose to use the drug for other problems if he thinks it might be helpful.

How to administer trifluoropyridine/triplicate:

    Trifluridine / tipiricil is an oral tablet.
    Take it twice a day within one hour of eating in the morning and evening.
    Take a glass of water.
    Tablets have two advantages, and you may need to combine the two advantages to achieve your       specific dose. Follow your instructions carefully.
    Trifluoropyridine/tepicillate is usually taken daily on days 1 to 5 and 8 to 12 of a 28-day cycle.

The amount of trifluoropyridine/triplicate you will get depends on many factors, including height and weight, general health or other health issues, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

Abatacept (Orencia) , How to Take it, Side effects

Abatacept is available either in infusible or injectable form. The infusion is given intravenously (through a needle placed in a vein) at 0, 2 and 4 weeks, then monthly thereafter in your doctor's office or at an infusion centre. The dosage is adjusted according to the patient’s weight. It takes 30 minutes to receive the whole infusion.

The injectable form of abatacept is injected under the skin at home once a week.  It can be administered by the patient or another member of the home. Studies have shown this formulation to be as safe and effective as the infusion.

Although some patients feel relief within the first month of treatment, usually three months of continuous treatment are needed to get the full effect of the medication.

Side Effects

The most common side effects reported were those associated with headaches, common colds, sore throat, and nausea.  Rarely, patients may develop infusion reactions while receiving abatacept including a severe allergic reaction, hives, shortness of breath, and low blood pressure.  Nurses will monitor you and your vital signs throughout the infusion.  Pre-medications such as Tylenol or Benadryl can be used preventively and can be discussed with your doctor.

The most important side effect is the risk of developing a serious infection, including pneumonia, tuberculosis, and others. pharma consulting companies Patients are tested for possible tuberculosis with a skin test or blood test before starting this drug. Abatacept should not be combined with another biologic drug, because the combination can increase the risk of contracting a serious infection.

It is not yet clear if the risk of cancer is higher in patients on abatacept compared to patients with other drugs. Nevertheless, larger reports should demonstrate if there is any trend of possible cancer risk.

Monitoring by your rheumatologist is necessary while taking this medication and lab monitoring may be needed periodically as well.

Using two biologic drugs (such as TNF-alpha blockers and abatacept) at the same time carries a high risk of developing serious infections. pharmaceutical consulting services Patients who have previously received another biologic drug, such as a TNF-alpha blocker can receive abatacept after the first drug has been stopped.

Patients with diabetes mellitus should be aware that sugars in the infusion form of abatacept may cause false high blood sugar levels. You should discuss with your physician how to properly monitor this.

About Jardiance(Empagliflozin) , How jardiance helps type2 Diabetes, Mechanism

Jardiance is a once-daily oral medication used to control blood sugar levels in patients with type 2 diabetes.

This is achieved by helping the kidneys remove glucose from the blood through urine.

Jardiance is not used to lose weight or control blood pressure, but it can help you at the same time. pharma consulting companies. It is used as part of a treatment plan, which may include exercise, diet and special medical care.

The drug was approved by the European Commission in May 2014. As a relatively new drug, its long-term effects within a few years are unclear.

About Jardiance

    Product Name: Jardiance
    Common name: Empagliflozin
    Drug category: SGLT2 inhibitor
    Manufacturers: Boehringer Ingelheim and Eli Lilly and Diabetes

How Jardiance helps type 2 diabetes

By expelling excess glucose from the urine, Jardinance helps improve blood sugar control in patients with type 2 diabetes. named Patient supply This can lead to improved HbA1c levels, thereby reducing the risk of diabetes-related complications.

Since calories in glucose are also excreted from the body, the use of Jardiance may cause weight loss. Since type 2 diabetes is closely related to body weight-about 90% of newly diagnosed type 2 diabetes exceeds its ideal body weight-this helps maintain healthy body weight.

Jardiance is used as part of the treatment plan, in addition to Jardiance treatment, it is also important to maintain other aspects (such as physical exercise).

Mechanism of action

Empagliflozin is an SGLT2 inhibitor, a drug class that helps prevent sodium and glucose transporters that are filtered from the blood as the kidney is reabsorbed back into the blood.

Empagliflozin allows large amounts of sugar to be removed by urination. SGLT2 protein accounts for 90% of glucose reabsorbed into the blood.

Darzalex (daratumumab) dosing, indications, interactions ...

What is Darzalex?

Daratumumab is an anti-cancer drug. It binds to CD38, which overexpresses multiple myeloma cells.

Darzalex is a prescription drug used to treat adults with multiple myeloma. It is unclear whether Darzalex is safe and effective in children.

What are the important side effects of Darzalex?

Darzalex may cause serious reactions, including:

1.Infusion reaction. 

Infusion reactions are common in Darzalex and can be severe. If you have an infusion reaction, your health care provider may temporarily stop the infusion or completely stop treatment with Darzalex. If you experience any of the following symptoms, please seek medical help immediately:

• Shortness of breath or difficulty breathing
• Dizziness or lightheadedness (hypotension)
• Cough
• Respite
• Tight throat
• Runny or stuffy nose
• Headache
• Itching
• Nausea
• Vomiting
• Chills
• Heat

2. Blood Test Changes

Darzalex will affect the results of blood tests to match your blood type. After you take the last dose of Darzalex, these changes can last up to 6 months. Before starting treatment with Darzalex, your health care provider will perform a blood test to match your blood type. Before accepting a blood transfusion, please inform all healthcare providers that you are receiving Darzalex treatment.

3. Blood Cell Count Decreases 

Darzalex reduces the number of white blood cells that help fight infection, and blood cells called platelets help clot blood. Your healthcare provider will check your blood count during treatment with Darzalex. If you have a fever or signs of bruising or bleeding, please tell your healthcare provider.

The most common side effects of Darzalex include:

• Tired
• Nausea
• Diarrhea
• Shortness of breath
• Difficulty sleeping
• Feel weak
• Loss of appetite
• Heat
• Cough
• Muscle cramps
• Backache
• Arthralgia
• Vomiting

Tell your healthcare provider if you have any side effects that are bothering you or will not go away.

These are not all possible side effects of Darzalex. Call your doctor for medical advice about side effects. You can report side effects to FDA at 1-800-FDA-1088.

The fact of DARZALEX (Daratumumab) injection 100mg / 5ml and 400mg / 20ml vials?

Medical Name: DARZALEX

Common Name: Daratumumab

Approval Date: November 16, 2015

Company Name: Janssen Biotech

Available Forms and Strengths: 100mg / 5ml and 400mg / 20ml injections

What are the indications and usage?

DARZALEX is a kinase inhibitor suitable for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. Is a monoclonal antibody against human CD38, suitable for the treatment of patients with multiple myeloma, these patients have received at least three previous therapies, including proteasome inhibitors (PI) and immunomodulators, or PI and immunomodulators Double resistance?

The instruction has been approved under accelerated approval based on the response rate

Dosage and Administration

Recommended dosage and schedule

Manage medications before and after infusion.

After dilution in 0.9% sodium chloride injection (USP), it can only be administered as an intravenous infusion.

DARZALEX should be managed by medical staff and should immediately use first aid equipment and appropriate medical support to manage the infusion reactions that occur.

If you want to get more information  Click here

Multiple Myeloma: Symptoms, Causes, Diagnosis and Treatment

Multiple Myeloma

Multiple myeloma, also called Kahler's disease, is a blood cancer. There is no cure, but treatment can slow its spread and sometimes even make symptoms disappear.

A type of white blood cells called plasma cells produce antibodies that fight infections in the body. When you have multiple myeloma, these cells will multiply in the wrong way. They allow too much protein (called immunoglobulin) to enter the bones and blood.

Plasma Cell Carcinoma

Plasma cells are a type of white blood cell in the bone marrow. In this case, a group of plasma cells will become cancerous and multiply. The disease can damage bones, the immune system, kidneys and the number of red blood cells.

Symptoms may not be present or specific, such as loss of appetite, bone pain and fever.

Treatments include drugs, chemotherapy, corticosteroids, radiation or stem cell transplantation.

Multiple myeloma is a cancer that forms in white blood cells called plasma cells. Plasma cells help you fight infections by making antibodies that recognize and attack bacteria. Multiple myeloma causes cancer cells to accumulate in the bone marrow and crowd out healthy blood cells.

Symptoms: fatigue; fracture; bone pain ...

Plasma Cell Disease

Multiple myeloma is one of many diseases that can cause plasma cell problems. Others include:

• Monoclonal gammopathy. This is when your plasma cells make too many copies of an antibody. Multiple myeloma is a form of this disease. Another form, monoclonal gammopathy of unknown significance, may make you more likely to develop multiple myeloma.
• Solitary plasmacytoma. This is like multiple myeloma, but it causes a single abnormal plasma cell growth, not many of them. It can occur inside or outside the bone. It may also increase the risk of multiple myeloma.
• Light chain amyloidosis. This can cause abnormal plasma cells in your bone marrow, but they are fewer than multiple myeloma.
• Waldenstrom macroglobulinemia. This is a type of monoclonal gamma disease and non-Hodgkin's lymphoma (cancer of the lymphatic system). The cancer cells have the characteristics of plasma cells and lymphoid tissues.

Etiology and risk factors of multiple myeloma

Experts are not sure what causes multiple myeloma. However, you are more likely to obtain it if:

• You are over 65 years old
• You are a male
• You are african american
• You have family
• You are overweight or obese
• You are radiated
• You have been exposed to chemicals used in rubber manufacturing, wood processing or fire fighting; or in herbicides

Symptoms of Multiple Myeloma

Early on, you may not notice any symptoms. But as time goes by, you may:

• Bone pain
• Weakness and fatigue
• Weight loss and loss of appetite
• Upset stomach
• constipation
• confusion
• Frequently infected
• thirst
• Weak or numb arms and legs

Diagnosis of Multiple Myeloma

If you perform other blood tests, your doctor may suspect multiple myeloma and display:

• Excessive calcium in the blood (hypercalcemia)
• Too few red blood cells (anemia)
• Kidney problems
• The total protein level in the blood is high, but a level called albumin is low (your doctor may say you have a "globulin gap")

Multiple Myeloma Complications

Multiple myeloma can cause the following problems:

• Bone problems. Your bones will weaken and cause fractures.
• Blood problems. You may have anemia, which means your body does not have enough red blood cells. This can make you tired, pale, and cause heart disease. You may have too few platelets, which makes your blood more difficult to clot.
• Infection. When you have myeloma, your body produces many weak antibodies, which will reject healthy antibodies, making it more difficult for you to fight infection. Lack of white blood cells also weakens your immune system.
• Kidney damage. Myeloma can block the kidneys and prevent them from filtering the way they should. This may cause kidney failure.

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Named Patient Supply - Licenced Medicines Access Program ...

The Named Patient Program (NPP) provides patients and doctors with commercially approved drugs that are not available in their home country. ... is approved and available in one country, but not approved in the country where the patient is located. Discontinued in the country where the patient is located but not in other countries

Naming patient plan

Alleviare Life Sciences Pvt. Ltd. is a consulting pharmaceutical company that specializes in naming patients. We assist patients to establish contact with real and authorized distributors of special medicines that are not or not approved in India.

Indian generic drugs

If some patients require certain high-quality generic drugs, we will also abide by the highest ethical standards in the way of operation, we will provide a variety of options, and we can provide you with professional convenience.

Provide medicines to patients in need through designated patient supply

Governments around the world have established relevant provisions that allow patients who have exhausted all alternative treatment options and do not meet the criteria for clinical trial entry to use the prescribed patient drug treatment plan before they are approved. These named patient plans are usually categorized by sympathetic use, expanded use, or designated patient supply labels. These rules are governed by national / regional definitions of access standards, data collection, promotion, and drug distribution

 control rules.

Information for patients

What is the procedure for naming patients?

The Named Patient Program (NPP) provides patients and doctors with commercially approved drugs that are not available in their home country. These drugs must be approved in at least one country before they can be imported into the country where the patient is based on NPP.

The medicine is called 2 names?

Many drugs have at least two different names:

Brand name-created by pharmaceutical companies that manufacture drugs.

Generic name – the name of the active ingredient in the medicine.

Use of compassion in medicine

Sympathetic drug use (or sometimes sympathetic drug use) refers to the use of unapproved new drugs to treat critically ill patients when no other treatment is available. Drugs that are being tested but not yet approved by the US Food and Drug Administration (FDA) are called research drugs.

Special license

Special drugs refer to unlicensed drugs that can meet the individual clinical needs of patients when there are no suitable licensed drugs. "Special drugs" account for about 1% of all prescription drugs in the UK, but account for more than 75,000 different prescription drugs.

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India Imports: Medicinal and Pharmaceutical Product

The United States relies heavily on drugs imported from China. Antibiotics, over-the-counter painkillers, and drugs that can relieve itching and swelling-many are imported from China.

Can prescription drugs be imported?

As mentioned above, although individuals are allowed to import their own prescription drugs under limited circumstances, there is no “safe harbour” that allows the import of prescription drugs that violate federal laws, and these drugs are imported for commercial distribution or management of others.

Is it legal for me to import drugs personally?

In most cases, it is illegal for individuals to import drugs into the United States for personal use. ... for example, if a drug is approved by Health Canada (the equivalent of the Canadian FDA) but not yet approved by the FDA, the drug is not approved in the United States, so the import is illegal.

Can I prescribe in another country?

Even if you prepare a copy of the beneficiary and money used to pay for medicines, many countries do not allow pharmacies to fill out prescriptions outside their country. One solution is to have a local doctor explain your condition to obtain a new prescription that can be filled in locally.

Which country's pharmacy is the best?

Top Pharmacy and Pharmacology

Harvard University. ...

University of Cambridge. ...

National University of Singapore, Singapore. ...

University of Oxford. ...

Karolinska Institute of Sweden. ...

Monash University, Australia. ...

Imperial College London, United Kingdom. ...

The University of Tokyo, Japan.

As of September 2020, the value of pharmaceutical products imported from India was approximately 235 billion Indian rupees.

Import Value of Indian Pharmaceutical Products, 2010-2020

As of September 2020, the value of pharmaceutical products imported from India was approximately 235 billion Indian rupees. This is a decrease from the previous year's import value (444.4 billion rupees).

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