DOSAGE AND ADMINISTRATION ORENCIA

Adult rheumatoid arthritis

For adult patients with RA, ORENCIA can be administered by intravenous infusion or subcutaneous injection.

ORENCIA can be used as a monotherapy or with DMARDs other than TNF antagonists.
IV regimen

Orerncia lyophilized powder should be diluted and used after dilution [see adult psoriatic arthritis], and intravenous infusion of 30 minutes according to the dose based on the weight range specified in Table 1. After the first intravenous administration, intravenous infusion should be given at 2 and 1. 4 weeks after the first infusion and every 4 weeks thereafter.

Subcutaneous dosing regimen

ORENCIA 125 mg in a prefilled syringe or in the ORENCIA ClickJect™ auto-injector should be injected subcutaneously once a week [see preparation and dosing instructions for intravenous infusion], and can be started with or without an intravenous dose . named patient program For patients starting treatment with an intravenous loading dose, ORENCIA should be started with a single intravenous infusion (according to the weight category listed in Table 1), and then the first 125 mg subcutaneous injection should be given within the same day of the intravenous infusion.

Patients transitioning from Orencia intravenous therapy to subcutaneous administration should be given the first subcutaneous dose instead of the next scheduled intravenous dose.
Juvenile idiopathic arthritis

For patients with juvenile idiopathic arthritis (JIA), ORENCIA can be administered by intravenous infusion (6 years and older) or subcutaneous injection (2 years and older). No intravenous administration was given to patients under 6 years of age.

ORENCIA can be used as a monotherapy or concurrently with methotrexate.
IV regimen

ORENCIA should be administered as a 30-minute intravenous infusion based on body weight. Pediatric patients:

 People weighing less than 75 kg should be administered ORENCIA at a dose of 10 mg/kg [see Adult Psoriatic Arthritis] After the adult intravenous administration regimen (see Table 1), Orencia should be given a body weight of 75 kg or more, and the maximum dose should not exceed 1,000 mg.

After the initial administration, ORENCIA should be administered 2 and 4 weeks after the first infusion and every 4 weeks thereafter. named patient basis,The unused part of the sample bottle must be discarded immediately.
Subcutaneous dosing regimen

Orencia for subcutaneous injection should be started without an intravenous dose, and the dose based on the weight range specified in Table 2 should be used.