Zavesca (miglustat capsules, 100 mg) is an inhibitor of
glucosylceramide synthase, which is the first glucosyltransferase
responsible for the synthesis of most glycosphingolipids.
Zavesca is an N-alkylated imino sugar, which is a synthetic analog of D-glucose.
The
chemical name of miglustat is 1,5-(butylimino)-1,5-dideoxy-D-glucitol,
the chemical formula is C10H21NO4, and the molecular weight is 219.28.
Miglustat
is a white to off-white crystalline solid with a bitter taste. It is
highly soluble in water (>1000 mg/mL is free base).
Zavesca is available in hard gelatin capsules, each capsule containing 100 mg of miglustat orally. named patient program,
Each Zavesca 100 mg capsule also contains sodium starch glycolate,
povidone (K30) and magnesium stearate. The ingredients in the capsule
shell include gelatin and titanium dioxide, and the shell is printed
with edible ink composed of black iron oxide and shellac.
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