Overian Cancer Type And Their Stages ?

 Stages

If a healthcare professional diagnoses ovarian cancer, they will need to determine the stage and grade to decide on a treatment plan.

The stage Trusted Source refers to how far the cancer has spread. For example:

• Localized: Cancer cells affect only the ovaries or fallopian tubes and have not spread elsewhere.
• Regional: Cancer has spread to nearby organs, such as the uterus.
• Distant: Cancer is present elsewhere in the body. It now affects other organs, such as the lungs or liver.

The grade, meanwhile, refers to how abnormal the cancer cells appear.

Getting an early diagnosis usually means that treatment can be more effective. However, other factors can affect this.

These factors include the person’s age and overall health and the type or grade of the cancer cell, as some types are more aggressive than others.

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Types

There are over 30 types of ovarian cancer, depending on the type of cell in which they start.

There are three common cell types:

• epithelial cells, which occur in the lining of the surface of the ovary
• germ cells, which will become eggs for reproduction
• stromal cells, which release hormones and link up the structures of the ovaries

Epithelial tumors are the most common and the most invasive. They occur in around 85–90% of people with ovarian cancer.

Germ cell tumors are often benign. In 90% of cases that become cancerous, treatment is effective.

Overian cancer Product is available to treat to treat this cancer. Buy medicine and order online Named Patient Medicines  

How are hereditary conditions treated?

Genetic disorder 

Numerous hereditary issues result from quality changes that are available in basically every cell in the body. Therefore, these issues regularly influence many body frameworks, and most can't be restored. Be that as it may, approaches might be accessible to treat or deal with a portion of the related signs and indications.

For a gathering of hereditary conditions called innate blunders of digestion, which
result from hereditary changes that upset the development of explicit proteins, medicines now and again incorporate dietary changes or substitution of the specific compound that is absent. Restricting specific substances in the eating regimen can assist with forestalling the development of possibly harmful substances that are typically separated by the catalyst. Now and again, compound substitution treatment can assist make with increasing for the catalyst lack. These medicines are utilized to oversee existing signs and side effects and may assist with forestalling future confusions. An illustration of a characteristic blunder of digestion is phenylketonuria (PKU), under named patient program we provides medicines to patients who exhausted all alternative treatment option. 

For other hereditary conditions, treatment and the board methodologies are intended to work on specific signs and indications related with the issue. These methodologies change by jumble and are explicit to a singular's wellbeing needs. For instance, a hereditary issue related with a heart deformity may be treated with a medical procedure to fix the imperfection or with a heart relocate. Conditions that are described by flawed platelet development, like sickle cell infection, can some of the time be treated with a bone marrow relocate. Bone marrow transplantation can permit the arrangement of typical platelets and, whenever done right off the bat throughout everyday life, may assist with forestalling episodes of torment and other future inconveniences.

Some hereditary changes are related with an expanded danger of future medical issues, like specific types of malignant growth. One notable model is familial breast cancer  identified with changes in the BRCA1 and BRCA2 qualities. The board might incorporate more incessant disease screening or preventive (prophylactic) medical procedure to eliminate the tissues at most noteworthy danger of becoming malignant.

Hereditary issues might cause such serious medical conditions that they are incongruent with life. In the most serious cases, these conditions might cause an unnatural birth cycle of an impacted undeveloped organism or hatchling. In different cases, impacted newborn children might be stillborn or kick the bucket soon after birth.  Hardly any imported medicines in india  are accessible for these serious hereditary conditions, wellbeing experts can regularly give strong consideration, like help with discomfort or mechanical breathing help, to the impacted person.

Most treatment procedures for hereditary issues don't change the basic hereditary transformation; be that as it may, a couple of issues have been treated with quality treatment. This exploratory strategy includes changing an individual's qualities to forestall or treat a sickness. Quality treatment, alongside numerous other treatment and the board approaches for hereditary conditions, are under study in clinical preliminaries.

Side Effects of Imatinib

 Upset stomach, nausea/vomiting, diarrhea, headache, muscle/joint pain, muscle cramps, dizziness, blurred vision, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, unusual tiredness, sudden/unexplained weight gain, swelling hands/ankles/feet/abdomen, swelling around the eyes, shortness of breath, fast heartbeat, black/bloody stools, vomit that looks like coffee grounds, symptoms of liver disease (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine).

This medication may lower your ability to fight infections. This may make you more likely to get a serious infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills).

Imatinib sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). To lower your risk, drink plenty of fluids unless your doctor directs you otherwise. Also, your doctor may prescribe an additional medication. Tell your doctor right away if you have symptoms such as: low back/side pain (flank pain), signs of kidney problems (such as painful urination, pink/bloody urine, change in the amount of urine), muscle spasms/weakness.

Imatinib can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice any other effects not listed above, contact your doctor or pharmacist.

How to use Bendamustine | Indian Generic Medicine

 According to the doctor's instructions, the healthcare professional injects the drug slowly into the vein.

The dosage depends on your health, size, and response to treatment. Before each cycle, you should perform blood tests to find the best dose for you and determine if you have to wait before you can receive this medicine again.

Before you receive this medication, your doctor may direct you to take antipyretics, antihistamines, and corticosteroids (such as dexamethasone) to help prevent side effects. Use these additional medicines exactly as directed by your doctor. (See also the side effects section.)

If bendamustine leaks from a vein into the surrounding area, it may cause severe skin and tissue damage. If you feel pain, irritation, redness or swelling at the injection site, tell your healthcare professional immediately. Timely treatment of leakage will help reduce discomfort and possible skin damage.

Melphalan Uses And Side Effects

 This medication is used to treat certain types of cancer (such as multiple myeloma, ovarian). Melphalan belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.

How to use Melphalan Tablet

Take this medication by mouth as directed by your doctor, usually once a day. Unless otherwise directed by your doctor, drink plenty of fluids to help prevent side effects.

The dosage and treatment schedule are based on your medical condition and response to treatment. Carefully follow your doctor's directions for taking this medication.

Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

It may take several months before you see a benefit from this drug.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Side Effects

Nausea, vomiting, diarrhea, lip/mouth sores, and loss of appetite may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Tell your doctor right away if you have any serious side effects, such as: shortness of breath, stopped menstrual periods (women), symptoms of liver problems (such as stomach/abdominal pain, yellowing eyes/skin, dark urine).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Ledifos 90mg/400mg Introduction, Uses and Benifits.

 Ledifos 90mg/400mg tablets are a combination of two antiviral drugs. This prescription medicine is used to treat chronic hepatitis C virus (HCV) infection. It fights the virus to resolve the infection.

Ledifos 90mg/400mg tablets should be taken according to the prescribed dose and duration. It can be taken with or without food, but at the same time every day. It is recommended not to consume more than the recommended dose. If you have any health conditions, such as liver or kidney disease, be sure to tell your doctor. Drinking alcohol with this medication is harmful, so it is recommended to limit or avoid drinking alcohol. The course of medication should be completed to achieve better results.

Common side effects of this drug are tiredness and headache. You should drink plenty of water and eat a healthy diet to prevent or overcome side effects. Before taking the medicine, please tell your doctor if you are taking other medicines or supplements.

Uses of Ledifos Tablet

    Treatment of Chronic hepatitis C virus (HCV) infection 

Benefits of Ledifos tablets

In the treatment of chronic hepatitis C virus (HCV) infection

Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). When the infection enters a long-term phase, it is called chronic hepatitis C virus infection. Ledifos 90mg / 400mg Tablet can prevent the spread of hepatitis C virus in the body, thereby reducing the amount of hepatitis C virus. This will help control the infection and help you recover faster. It is important to take the medicine according to the prescription recommended by your doctor.

IMATINIB TABLETS VEENAT 400 MG, Introduction, Uses.

Veenat 400 Tablet belongs to a class of drugs called tyrosine kinase inhibitors. It is used to treat blood cancers (chronic myeloid leukemia and acute lymphocytic leukemia) and gastrointestinal stromal tumors.

Veenat 400 tablets should be taken with food, but it is best to take them at the same time every day for maximum benefit. You should continue taking it as long as your doctor recommends it. The duration of treatment varies according to your needs and response to treatment. Taking the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel these benefits, but unless your doctor tells you, do not stop taking it.

The most common side effects of the drug include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue and abdominal pain. If you experience unexpected rapid weight gain, please tell your doctor. While you are taking this medicine, your doctor may recommend that you regularly monitor blood cells and liver function. If you feel dizzy and blurred vision, do not drive or do anything that requires concentration.

Many other medicines may affect or be affected by this medicine, so please let your medical team know about all medicines you are taking. This medication is not recommended during pregnancy or during breastfeeding. During treatment, both men and women should use effective contraceptive methods, which is important to avoid pregnancy.

Uses of Veenat Tablet

    Blood cancer (Chronic myeloid leukaemia)

    Blood cancer (Acute lymphocytic leukemia)

    Gastrointestinal stromal tumour

Lenalidomide Capsule Uses

 Lenalidomide is used to treat various types of cancer. It works by slowing down or stopping the growth of cancer cells. It can also be used to treat anemia of certain blood/bone marrow diseases (myelodysplastic syndrome-MDS). Lenalidomide can reduce the need for blood transfusions. Lenalidomide is not recommended to treat certain types of cancer (chronic lymphocytic leukemia) because it increases the risk of serious heart-related side effects and death. If you have this cancer, talk to your doctor about the risks of using this medicine.

How to use lenalidomide capsules

Please read the Medication Guide provided by your pharmacist before starting lenalidomide and every time you supplement. If you have any questions, please consult your doctor or pharmacist.

Follow your doctor's instructions to take this medication by mouth, with or without food, usually once a day. Swallow the whole medicine with water. For the treatment of certain diseases, you may be instructed to take the drug in cycles (once a day for 21 days, then stop the drug for 7 days). The dosage depends on your medical condition, response to treatment, and laboratory test results. Make sure to follow your doctor's instructions carefully.

Do not open, chew or break the capsule, and do not over-process the capsule. If any powder in the capsule gets on the skin, wash the area with soap and water.

Because the drug can be absorbed through the skin and lungs, and may harm an unborn baby, pregnant women or women who may become pregnant should not use the drug or inhale dust from broken capsules. Everyone should wash their hands thoroughly after using the drug.

Use this medication regularly to get the most benefit from it. Remember to take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

BORTEZOMIB FOR INJECTION BORTENAT LYOPHILIZED USES AND SIDE EFFECTS

 This medication is given by a healthcare professional by intravenous injection or under the skin. If you receive this medication under the skin, make sure to change the injection site every time to reduce the damage under the skin. The dosage depends on your size, medical condition, laboratory tests, and response to treatment.

To prevent dehydration, be sure to drink plenty of fluids when using this medication. If you have any questions, please consult your doctor or pharmacist.

Dizziness, dizziness, nausea, vomiting, loss of appetite, diarrhea, constipation, fatigue, weakness, or pain/redness at the injection site may occur. Nausea, vomiting and diarrhea can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea, vomiting, and diarrhea. If these effects persist or worsen, please inform your doctor or pharmacist immediately.

To reduce the risk of dizziness and dizziness, get up slowly when lifting from a sitting or lying position.

People who use this drug may have serious side effects. However, your doctor prescribed this medicine because he or she judged that the benefits to you outweigh the risks of side effects. The doctor's careful monitoring may reduce your risk.

Bortezomib sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). To reduce the risk, your doctor may add medicine and tell you to drink plenty of water. Tell your doctor immediately if you have the following symptoms: lower back/side pain (back pain), signs of kidney problems (such as painful urination, pink/bloody urine, changes in urine output), muscle cramps/weakness.

If you have any serious side effects, please tell your doctor immediately, including: tingling/numbness/pain/arm/leg fever, syncope, severe headache, mental/mood changes (such as confusion), severe abdominal/abdominal pain, signs of liver disease (Such as yellow eyes/skin, yellow urine), heart failure symptoms (such as shortness of breath, ankle/foot swelling, abnormal fatigue, abnormal weight/sudden increase).

If you have any very serious side effects, seek medical help immediately, including: chest pain, difficulty breathing, vision changes, seizures, weakness on one side of the body, and difficulty speaking.

This medication can reduce blood cells, which can lead to anemia, reduce the body's ability to fight infection or cause easy bruising/bleeding. Tell your doctor immediately if you experience any of the following symptoms: easy bleeding/bruising, black/tar-like stools, vomit that looks like coffee grounds, signs of infection (such as persistent sore throat, fever, chills), abnormal Tired, pale skin.

Very severe allergic reactions to this drug are rare. However, if you notice any symptoms of a severe allergic reaction, including skin rash, itching/swelling (especially face/tongue/throat), severe dizziness, and difficulty breathing, please seek medical help immediately.

Bortezomib usually causes a rash, which is usually not serious. However, you may not be able to tell it apart from the rare rash, which may be a sign of a serious reaction. If a rash occurs, seek medical help immediately.

Melphalan Tablet Side Effects

 There may be nausea, vomiting, diarrhea, lip/mouth sores and loss of appetite. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating a few small meals, not eating before treatment, or restricting the amount of activity may help reduce some effects. If these effects persist or worsen, please inform your doctor or pharmacist immediately.

Temporary hair loss may occur. After the treatment, the hair returned to normal growth.

People who use this drug may have serious side effects. However, your doctor prescribed this medicine because he or she judged that the benefits to you outweigh the risks of side effects. The doctor's careful monitoring may reduce your risk.

If you have any serious side effects, please tell your doctor immediately, such as: shortness of breath, menstruation stopped (in women), symptoms of liver disease (such as stomach/abdominal pain, yellow eyes/skin, dark urine).

Very severe allergic reactions to this drug are rare. However, if you notice any symptoms of a severe allergic reaction, such as rash, itching/swelling (especially face/tongue/throat), severe dizziness, and difficulty breathing, please seek medical help immediately.

This is not a complete list of possible side effects. If you notice other effects not listed above, please contact your doctor or pharmacist

MELPHALAN USES

 This drug is used to treat certain types of cancer (for example, multiple myeloma, ovarian cancer). Melphalan belongs to a class of drugs called alkylating agents. It works by slowing down or stopping the growth of cancer cells.

How to use Melphalan tablet

Follow your doctor’s instructions to take this medication by mouth, usually once a day. Unless your doctor instructs otherwise, drink plenty of water to help prevent side effects.

The dosage and treatment plan depend on your medical condition and response to treatment. Take the medicine carefully as directed by your doctor.

Do not increase the dose or take this drug more than specified. Your condition will not get better soon, and the risk of serious side effects will increase.

It may take several months for you to benefit from this medicine.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

ORENCIA SIDE EFFECTS

 

 Because clinical trials are conducted under widely varying and controlled conditions, it is impossible to directly compare the adverse reaction rate observed in the drug clinical trial with the incidence in the clinical trial of another drug, and may not be predictable in clinical practice The adverse reaction rate observed in the wider patient population.

Like all therapeutic proteins, it has the potential for immunogenicity. The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay. In addition, the incidence of positive antibodies (including neutralizing antibodies) observed in the assay may be affected by several factors, including the assay method, sample processing, sample collection time, concomitant medications and underlying diseases. named patient supply For these reasons, comparing the incidence of abatacept antibodies in the studies described below with the incidence of antibodies in other studies or other products may be misleading.

Clinical research experience of Orencia intravenous injection in adult RA patients

The data described in this article reflect the intravenous use of Orencia in patients with active RA in a placebo-controlled study (Orencia patients in 1955, 989 placebo patients).named patient medicines The double-blind placebo-controlled period of the study was 6 months (258 ORENCIA patients, 133 placebo) or 1 year (1697 ORENCIA patients, 856 placebo). Some of these patients received biological DMARD therapy, such as TNF blockers (204 ORENCIA patients and 134 placebo patients).

Most patients in RA clinical studies receive one or more of the following ORENCIA concomitant drugs: methotrexate, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, TNF blockers, azathioprine, chloroquine, gold, hydroxy Chloroquine, leflunomide, sulfasalazine and anakinra.

The most serious adverse reactions are serious infections and malignant tumors.

The most common adverse events (occurring in ≥10% of patients treated with ORENCIA) were headache, upper respiratory tract infection, nasopharyngitis, and nausea.

The most common adverse event (interruption or discontinuation of ORERNCIA) of clinical intervention is caused by infection. pharmaceutical consulting companies The most frequently reported infections that caused dose interruptions were upper respiratory tract infection (1.0%), bronchitis (0.7%), and herpes zoster (0.7%). The most common infections leading to discontinuation are pneumonia (0.2%), local infection (0.2%) and bronchitis (0.1%).

 

What Is ALS? What Are the Types and Causes?

 

ALS is short for amyotrophic lateral sclerosis. You might also have heard it called Lou Gehrig's disease, after the baseball player who was diagnosed with it in the 1930s. A French doctor named Jean-Martin Charcot discovered the condition in 1869.

ALS is a progressive disease, which means it gets worse over time. It affects nerves in your brain and spinal cord that control your muscles. As your muscles get weaker, it gets harder for you to walk, talk, eat, and breathe.
ALS and Motor Neurons

It’s a disease that affects your motor neurons. These nerve cells send messages from your brain to your spinal cord and then to your muscles. You have two main types:

    Upper motor neurons: Nerve cells in the brain.
    Lower motor neurons: Nerve cells in the spinal cord to muscle.

These motor neurons control all your voluntary movements -- the muscles in your arms, legs, and face. They tell your muscles to contract so you can walk, run, pick up your smartphone, chew and swallow food, and even breathe.

ALS is one of a few motor neuron diseases. Some others include:

    primary lateral sclerosis (PLS)
    progressive bulbar palsy (PBP)
    pseudobulbar palsy

What Happens When You Have ALS

With ALS, motor neurons in your brain and spinal cord break down and die.

When this happens, your brain can't send messages to your muscles anymore. Because the muscles don't get any signals, they become very weak. This is called atrophy. In time, the muscles no longer work and you lose control over their movement.

At first, your muscles get weak or stiff. You may have more trouble with fine movements -- such as trying to button a shirt or turn a key. You may stumble or fall more than usual. After a while, you can't move your arms, legs, head, or body.

Eventually, people with ALS lose control of their diaphragm, the muscles in the chest that help you breathe. Then they can't breathe on their own and will need to be on a breathing machine.

The loss of breathing causes many people with ALS to die within 3 to 5 years after they're diagnosed. Yet some people can live more than 10 years with the disease.

People with ALS can still think and learn. They have all of their senses -- sight, smell, hearing, taste, and touch. Yet the disease can affect their memory and decision-making ability.

ALS isn't curable. Yet scientists now know more about this disease than ever before. They are studying treatments in clinical trials.

ORENCIA

ORENCIA® (abatacept) is a selective T cell costimulatory modulator. ORENCIA is a soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), which is combined with the modified Fc (hinge, CH2 and CH3 domains) of human immunoglobulin G1 (IgG1) Partially connected. Abatacept is produced in a mammalian cell expression system through recombinant DNA technology. The apparent molecular weight of abatacept is 92 kilodaltons.

ORENCIA injection is a lyophilized powder for intravenous infusion. ORENCIA injection is a sterile, white, preservative-free lyophilized powder that can be reconstituted and diluted before intravenous administration. After rebuilding the lyophilized powder with 10 mL of sterile water for injection (USP), the OERNCIA solution was clear, colorless to light yellow, and the pH was 7.2 to 7.8. Each single-use ORENCIA injection bottle provides 250 mg of abatacept, maltose (500 mg), sodium dihydrogen phosphate (17.2 mg) and sodium chloride (14.6 mg) for administration.

ORENCIA injection is a sterile, preservative-free, transparent to slightly opalescent, colorless to light yellow solution, and the pH range for subcutaneous administration is 6.8 to 7.4. ORENCIA injection is provided in the form of a single-dose prefilled syringe or a single-dose ClickJect auto-injector.

ORENCIA® is suitable for reducing the symptoms and signs of adult patients with moderate to severe active rheumatoid arthritis, causing major clinical reactions, inhibiting the progression of structural damage and improving physical function. In addition to tumor necrosis factor (TNF) antagonists, OERNCIA can also be used as a monotherapy or in conjunction with disease-modifying anti-rheumatic drugs (DMARD).
Juvenile idiopathic arthritis

ORENCIA is indicated for alleviating signs and symptoms of adolescent idiopathic arthritis with moderately to severely active polyarticular joints aged 2 years and older. ORENCIA can be used as a monotherapy or in combination with methotrexate (MTX).
Adult Psoriatic Arthritis (PsA)

ORENCIA is designated for the treatment of adult patients with active psoriatic arthritis (PsA).
Important usage restrictions

ORENCIA should not be used simultaneously with TNF antagonists. It is not recommended to use ORENCIA with other biological rheumatoid arthritis (RA) treatments (such as anakinra).

Overview of Elaprase

Elaprase (idursulfase) is an IV infusion used to treat some of the symptoms of a genetic condition called Hunter's syndrome, also called mucopolysaccharidosis (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis). Idursulfase contains a natural enzyme that some people lack because of a genetic disorder. Elaprase helps replace this missing enzyme.

Hunter syndrome is a metabolic disorder in which the body lacks the enzyme needed to break down certain sugars and proteins. These substances can build up in the body, causing enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart problems, vision loss, and changes in mental or physical abilities.

Elaprase may improve walking ability in people with this condition. However, this medication is not a cure for Hunter syndrome.

Important information

Elaprase may improve walking ability in people with Hunter syndrome. However, Elaprase is not a cure for this condition.

Some side effects may occur during the infusion, or up to 24 hours afterward. Get emergency medical help if you have any signs of an allergic reaction: feeling like you might pass out; hives; trouble breathing; seizure (convulsions); swelling of your face, lips, tongue, or throat.

You may be more likely to have a reaction to Elaprase if you have a breathing disorder. named patient program,Tell your doctor if you have asthma or other lung disease.

CARBAGLU DOSAGE AND ADMINISTRATION

Recommended Dosage

CARBAGLU should be initiated as soon as the diagnosis of NAGS deficiency is suspected, which may be as soon as at birth, and managed by a physician and medical team experienced in metabolic disorders.

Initial Dosage

The recommended initial daily dosage of CARBAGLU in pediatric and adult patients for acute hyperammonemia is 100 mg/kg to 250 mg/kg divided into 2 to 4 doses and rounded to the nearest 100 mg (i.e., half of a CARBAGLU tablet). Concomitant administration of other ammonia lowering therapies is recommended.

Maintenance Dosage

The recommended daily maintenance dosage of CARBAGLU in pediatric and adult patients is 10 mg/kg to 100 mg/kg divided into 2 to 4 doses and rounded to the nearest 100 mg (i.e., half of a CARBAGLU tablet).

Therapeutic Monitoring

Closely monitor plasma ammonia levels. Titrate the CARBAGLU dosage to maintain the plasma ammonia level within the normal range for the patient's age, taking into consideration their clinical condition (e.g., nutritional requirements, protein intake, growth parameters, etc.).

Preparation And Administration

    Disperse CARBAGLU tablets in water. Do not swallow whole or crushed.
    Mix each 200 mg tablet in a minimum of 2.5 mL of water to yield a concentration of 80 mg/mL.
    CARBAGLU tablets do not dissolve completely in water and undissolved particles of the tablet may remain in the mixing container.
    Take CARBAGLU immediately before meals or feedings.
    The CARBAGLU suspension has a slightly acidic taste.
    For all preparations, use in foods or liquids, other than water, has not been studied clinically and is not recommended.

Preparation For Oral Administration In Pediatric And Adult Patients

    Add about 2.5 mL of water into a small cup for each CARBAGLU tablet or each ½ CARBAGLU tablet needed for the prescribed dose.
    Add the CARBAGLU tablets to the water in the cup.
    Carefully stir the tablet and water mixture.
    Swallow the mixture immediately. Pieces of the tablet may remain in the cup.
    Rinse the cup with additional water and swallow the mixture immediately. Repeat as needed until no pieces of the tablet are left in the cup.

Preparation For Nasogastric Tube Administration In Pediatric And Adult Patients

For patients who have a nasogastric tube in place, CARBAGLU should be administered as follows:

    Add about 2.5 mL of water into a small cup for each CARBAGLU tablet or each ½ CARBAGLU tablet needed for the prescribed dose.
    Add the CARBAGLU tablets to the water in the cup.
    Carefully stir the tablet and water mixture.
    Draw up the mixture into a catheter-tip syringe.
    Administer the mixture immediately through the nasogastric (NG) tube. Pieces of the tablet may remain in the catheter-tip syringe or NG tube.
    Flush immediately with 1 to 2 mL of additional water to clear the NG tube.
    Flush the NG tube again, as needed, until no pieces of the tablet are left in the syringe or NG tube.

Preparation For Oral Administration Using An Oral Syringe In Pediatric Patients

For administration via oral syringe, CARBAGLU should be administered as follows:

    Add about 2.5 mL of water into a small cup for each CARBAGLU tablet or each ½ CARBAGLU tablet needed for the prescribed dose.
    Add the CARBAGLU tablets to the water in the cup.
    Carefully stir the tablet and water mixture.
    Draw up the mixture in an oral syringe and administer immediately. Pieces of the tablet may remain in the oral syringe.
    Refill the oral syringe with a minimum volume of water (1 to 2 mL) and administer immediately.
    Flush the oral syringe again, as needed, until no pieces of the tablet are left in the syringe.

CARBAGLU DOSAGE AND INDICATION

 CARBAGLU tablets for oral suspension, contain 200 mg of carglumic acid. Carglumic acid, the active substance, is a Carbamoyl Phosphate Synthetase 1 (CPS 1) activator and is soluble in boiling water, slightly soluble in cold water, and practically insoluble in organic solvents.

Chemically carglumic acid is N-carbamoyl-L-glutamic acid or (2S)-2-(carbamoylamino) pentanedioic acid, with a molecular weight of 190.16.

Molecular Formula: C6H10N2O5

The inactive ingredients of CARBAGLU are croscarmellose sodium, hypromellose, microcrystalline cellulose, silica colloidal anhydrous, sodium lauryl sulfate, sodium stearyl fumarate.

INDICATIONS

Acute Hyperammonemia In Patients With NAGS Deficiency

CARBAGLU is indicated as an adjunctive therapy in pediatric and adult patients for the treatment of acute hyperammonemia due to the deficiency of the hepatic enzyme N-acetylglutamate synthase (NAGS). During acute hyperammonemic episodes, concomitant administration of CARBAGLU with other ammonia lowering therapies, such as alternate pathway medications, hemodialysis, and dietary protein restriction, is recommended.

Chronic Hyperammonemia In Patients With NAGS Deficiency

CARBAGLU is indicated as maintenance therapy in pediatric and adult patients for the treatment of chronic hyperammonemia due to deficiency of the hepatic enzyme N-acetylglutamate synthase (NAGS). Named patient program, During maintenance therapy, the concomitant use of other ammonia lowering therapies and protein restriction may be needed based on plasma ammonia levels.

What is CERDELGA and how is it used?

CERDELGA is a prescription medicine used for the long-term treatment of Gaucher disease type 1 (GD1) in adults.

CERDELGA is not used in certain people with Gaucher disease type 1. Your doctor will perform a test to make sure that CERDELGA is right for you.

It is not known if CERDELGA is safe and effective in children.

What are the possible side effects of CERDELGA?

See "What is the most important information I should know about CERDELGA?"

    CERDELGA, used with certain other medicines, may cause changes in the electrical activity of your heart (ECG changes) and irregular heart beat (arrhythmias). Tell your doctor if you have new symptoms such as palpitations, fainting, or dizziness.

The most common side effects of CERDELGA include: tiredness, headache, nausea, diarrhea, and pain in the arms, legs, back, or stomach (abdomen).

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of CERDELGA.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store CERDELGA?

    Store CERDELGA at room temperature between 68°F to 77 °F (20°C to 25 °C).
    Keep CERDELGA and all medicines out of reach of children.

General information about the safe and effective use of CERDELGA.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use CERDELGA for a condition for which it was not prescribed. Do not give CERDELGA to other people, even if they have the same symptoms you have. It may harm them.

If you would like more information, talk with your doctor. named patient india You can ask your doctor or pharmacist for information about CERDELGA that is written for health professionals.

Zavesca Indications & Dosage

 Zavesca is a glucosylceramide synthase inhibitor and is indicated as a monotherapy for adult patients with mild to moderate type 1 Gaucher disease. For these patients, enzyme replacement therapy is not a treatment option (for example, due to allergies, Hypersensitivity or poor venous access).

Dosage and administration

Management Instructions

Treatment should be guided by a doctor who has a good understanding of Gaucher's disease.

The recommended dose for adults with type 1 Gaucher disease is one 100 mg capsule orally three times a day. If a dose is missed, the next Zavesca capsule should be taken at the next scheduled time.

In some patients, due to adverse reactions such as tremor or diarrhea, it may be necessary to reduce the dose to 100 mg capsules once or twice a day.

Patients with renal insufficiency

For patients with mild renal insufficiency (adjusted creatinine clearance 50-70 mL/min / 1.73m²), the administration of Zavesca should be started with a dose of 100 mg twice a day. For patients with moderate renal insufficiency (adjusted creatinine clearance rate of 30-50 mL/min / 1.73m²), the administration of Zavesca should start with a daily dose of 100 mg capsules. Zavesca is not recommended for named patient basis with severe renal insufficiency (creatinine clearance <30 mL / min / 1.73m²)

ZAVESCA capsule uses

 

 Zavesca (miglustat capsules, 100 mg) is an inhibitor of glucosylceramide synthase, which is the first glucosyltransferase responsible for the synthesis of most glycosphingolipids.

Zavesca is an N-alkylated imino sugar, which is a synthetic analog of D-glucose.

The chemical name of miglustat is 1,5-(butylimino)-1,5-dideoxy-D-glucitol, the chemical formula is C10H21NO4, and the molecular weight is 219.28.



Miglustat is a white to off-white crystalline solid with a bitter taste. It is highly soluble in water (>1000 mg/mL is free base).

Zavesca is available in hard gelatin capsules, each capsule containing 100 mg of miglustat orally. named patient program, Each Zavesca 100 mg capsule also contains sodium starch glycolate, povidone (K30) and magnesium stearate. The ingredients in the capsule shell include gelatin and titanium dioxide, and the shell is printed with edible ink composed of black iron oxide and shellac.