Abatacept (Orencia) | named patient medicines

Abatacept (Orencia) is usually prescribed after the failure of disease-modifying antirheumatic drugs (DMARD) such as methotrexate but can be used as first-line treatment.

Abatacept is used to reduce inflammation symptoms such as swelling, pain and stiffness. In the long run, it is expected to prevent joint deformities and therefore helps maintain the range of motion.

It is commonly used in patients with moderate to severe rheumatoid arthritis who do not respond to one or more DMARDs (such as methotrexate or other biological drugs). named patient medicines Usually try DMARD first. Abatacept can be used alone or in combination with DMARDs, which makes it more effective, but it cannot be used with other biological drugs (such as TNF inhibitors). Its use in other diseases is still under study.

Unlike some other biological drugs, Abatacept does not block inflammatory proteins such as TNF-α antagonists. Abatacept attaches to the surface of inflammatory cells and blocks communication between these cells. By blocking this communication, Abatacept reduced inflammation.

Mekinist, How to give Mekinist, Mekinist is used to

Mekinist

Common name: Trimetinib

Mekinist is the trade name of the generic chemotherapy drug trametinib. named patient medicines In some cases, healthcare professionals may use the generic name melmetinib when referring to the trade name Mekinist.

Type of drug: Mekinist is a targeted therapy. It is an oral MEK inhibitor-(For more details, see "How the drug works" below.)

Mekinist is used to:

It is used to treat unresectable or metastatic melanoma caused by BRAF gene defects. named patient basis As shown by the FDA approved test, cancer must be (BRAF) positive.

 It is used in combination with Tafinlar® to treat metastatic non-small cell lung cancer (NSCLC). As shown by the FDA approved test, cancer must be BRAF positive.

Note: If a drug has been approved for one use, doctors may choose to use this drug for other problems if they think it may be helpful.

How to give Mekinist:

•     Mekinist is an oral medicine, once a day. At least 1 hour before a meal or 2 hours after a meal.
•     Take Mekinist in strict accordance with regulations.
•     Swallow Mekinist tablets whole. Do not crush or dissolve tablets.
•     Unless your healthcare provider tells you, do not change the dosage or stop Mekinist.
•     If you miss the dose, please remember as soon as possible. If it has been more than 12 hours since the missed dose, skip the missed dose and return to your normal time.
•     Do not take more than 1 dose of Mekinist at a time. If you take too much, call your health care provider immediately.
•     Store Mekinist in a refrigerator between 36°F and 46°F, not in the freezer.
•     Place the tablets in the bottle that comes in, and do not move them to the pill holder.
•     Store in the original container. Do not remove moisture-proof packaging. Avoid light.
•     Keep medicines away from children and pets.
•     The amount of Mekinist you will receive depends on many factors, your overall health condition or other health problems, and the type of cancer or condition being treated. The current recommendation is to take one tablet a day. Higher doses do not always produce better response and may lead to increased toxicity. Your doctor will determine your dosage and schedule.

Jardiance Storage, side effects of Jardiance?, What to do if you take an overdose, safety

 Jardiance storage

Jardiance should be stored at room temperature, away from moisture and heat, and kept in its original container. You must make sure that it is out of sight of children.
What are the side effects of Jardiance?

Side effects of Jardiance include:

    Problems with urination-frequent urination or very little urination
    Increased likelihood of urinary tract infection
    Signs of genital infection-such as pain, itching or rash
    Hypoglycemia-if taken with drugs that lower blood sugar levels
    Elevated cholesterol
    Feeling tired or dizzy

Please note that the above list is not exhaustive. imported medicines in India. You should refer to the patient information manual in the medication for a complete list of side effects.
What to do if you take too much medicine

If you overdose Jardiance, please contact your health team immediately for advice.
Long-term security

There are questions about whether SGLT2 inhibitors have harmful long-term effects on the kidneys. Invokana and Jardiance belong to the same drug category and are related to the decline of eGFR, which is a marker used to measure kidney function.

According to a report from the European Medicines Agency, the most common adverse reaction to Jardiance is hypoglycemia-this occurs when used with sulfonylurea or insulin.

The American Association of Clinical Endocrinologists will investigate whether SGLT2 inhibitors are responsible for the high incidence of diabetic ketoacidosis. Named Patient Program India, They plan to conduct this assessment in the fall of 2015.

Who is Jardiance Suitable for, Who Should not take, How Should be Taken

Who is Jardiance suitable for?

The National Institute of Clinical Excellence (NICE) recommends Jardiance to treat type 2 diabetes in the following situations:

    When diet and exercise do not provide adequate blood sugar control
    When metformin is inappropriate due to patient intolerance

If the patient has a significant risk of hypoglycemia or cannot take sulfonylurea drugs, it is also recommended to use Jardiance with metformin. named patient medicines. It can also be combined with metformin or sulfonylurea.

Who should not take Jardiance?

You should not take Jardiance if you have the following conditions:

    Type 1 diabetes
    Severe kidney problems

Before taking Jardiance, you should tell your doctor:

    Have kidney problems
    Are pregnant or plan to become pregnant
    Breastfeeding or planning to breastfeed
    Have liver disease
    Low blood pressure
    Taking antihypertensive drugs
    High cholesterol content
    Have a history of urinary tract infections
    65 years old
    Low salt diet

How should Jardiance be taken?

Jardiance is administered orally and is usually taken once a morning-it can be taken with or without food.

The drug was initially prescribed for a 10 mg dose, with a maximum dose of 25 mg. Pharmaceutical Consulting Company Although your doctor may change the dosage to ensure the best results, you should not take Jardiance at the recommended larger or smaller dosage.

If you miss a dose, you should take it as soon as you remember. However, you should not take an extra dose to make up for the medicine you missed. If the next scheduled dose is almost the same, you should skip the previously missed dose.

About Jardiance(Empagliflozin) , How jardiance helps type2 Diabetes, Mechanism

Jardiance is a once-daily oral medication used to control blood sugar levels in patients with type 2 diabetes.

This is achieved by helping the kidneys remove glucose from the blood through urine.

Jardiance is not used to lose weight or control blood pressure, but it can help you at the same time. pharma consulting companies. It is used as part of a treatment plan, which may include exercise, diet and special medical care.

The drug was approved by the European Commission in May 2014. As a relatively new drug, its long-term effects within a few years are unclear.

About Jardiance

    Product Name: Jardiance
    Common name: Empagliflozin
    Drug category: SGLT2 inhibitor
    Manufacturers: Boehringer Ingelheim and Eli Lilly and Diabetes

How Jardiance helps type 2 diabetes

By expelling excess glucose from the urine, Jardinance helps improve blood sugar control in patients with type 2 diabetes. named Patient supply This can lead to improved HbA1c levels, thereby reducing the risk of diabetes-related complications.

Since calories in glucose are also excreted from the body, the use of Jardiance may cause weight loss. Since type 2 diabetes is closely related to body weight-about 90% of newly diagnosed type 2 diabetes exceeds its ideal body weight-this helps maintain healthy body weight.

Jardiance is used as part of the treatment plan, in addition to Jardiance treatment, it is also important to maintain other aspects (such as physical exercise).

Mechanism of action

Empagliflozin is an SGLT2 inhibitor, a drug class that helps prevent sodium and glucose transporters that are filtered from the blood as the kidney is reabsorbed back into the blood.

Empagliflozin allows large amounts of sugar to be removed by urination. SGLT2 protein accounts for 90% of glucose reabsorbed into the blood.

Darzalex (daratumumab) dosing, indications, interactions ...

What is Darzalex?

Daratumumab is an anti-cancer drug. It binds to CD38, which overexpresses multiple myeloma cells.

Darzalex is a prescription drug used to treat adults with multiple myeloma. It is unclear whether Darzalex is safe and effective in children.

What are the important side effects of Darzalex?

Darzalex may cause serious reactions, including:

1.Infusion reaction. 

Infusion reactions are common in Darzalex and can be severe. If you have an infusion reaction, your health care provider may temporarily stop the infusion or completely stop treatment with Darzalex. If you experience any of the following symptoms, please seek medical help immediately:

• Shortness of breath or difficulty breathing
• Dizziness or lightheadedness (hypotension)
• Cough
• Respite
• Tight throat
• Runny or stuffy nose
• Headache
• Itching
• Nausea
• Vomiting
• Chills
• Heat

2. Blood Test Changes

Darzalex will affect the results of blood tests to match your blood type. After you take the last dose of Darzalex, these changes can last up to 6 months. Before starting treatment with Darzalex, your health care provider will perform a blood test to match your blood type. Before accepting a blood transfusion, please inform all healthcare providers that you are receiving Darzalex treatment.

3. Blood Cell Count Decreases 

Darzalex reduces the number of white blood cells that help fight infection, and blood cells called platelets help clot blood. Your healthcare provider will check your blood count during treatment with Darzalex. If you have a fever or signs of bruising or bleeding, please tell your healthcare provider.

The most common side effects of Darzalex include:

• Tired
• Nausea
• Diarrhea
• Shortness of breath
• Difficulty sleeping
• Feel weak
• Loss of appetite
• Heat
• Cough
• Muscle cramps
• Backache
• Arthralgia
• Vomiting

Tell your healthcare provider if you have any side effects that are bothering you or will not go away.

These are not all possible side effects of Darzalex. Call your doctor for medical advice about side effects. You can report side effects to FDA at 1-800-FDA-1088.

The fact of DARZALEX (Daratumumab) injection 100mg / 5ml and 400mg / 20ml vials?

Medical Name: DARZALEX

Common Name: Daratumumab

Approval Date: November 16, 2015

Company Name: Janssen Biotech

Available Forms and Strengths: 100mg / 5ml and 400mg / 20ml injections

What are the indications and usage?

DARZALEX is a kinase inhibitor suitable for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. Is a monoclonal antibody against human CD38, suitable for the treatment of patients with multiple myeloma, these patients have received at least three previous therapies, including proteasome inhibitors (PI) and immunomodulators, or PI and immunomodulators Double resistance?

The instruction has been approved under accelerated approval based on the response rate

Dosage and Administration

Recommended dosage and schedule

Manage medications before and after infusion.

After dilution in 0.9% sodium chloride injection (USP), it can only be administered as an intravenous infusion.

DARZALEX should be managed by medical staff and should immediately use first aid equipment and appropriate medical support to manage the infusion reactions that occur.

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Multiple Myeloma: Symptoms, Causes, Diagnosis and Treatment

Multiple Myeloma

Multiple myeloma, also called Kahler's disease, is a blood cancer. There is no cure, but treatment can slow its spread and sometimes even make symptoms disappear.

A type of white blood cells called plasma cells produce antibodies that fight infections in the body. When you have multiple myeloma, these cells will multiply in the wrong way. They allow too much protein (called immunoglobulin) to enter the bones and blood.

Plasma Cell Carcinoma

Plasma cells are a type of white blood cell in the bone marrow. In this case, a group of plasma cells will become cancerous and multiply. The disease can damage bones, the immune system, kidneys and the number of red blood cells.

Symptoms may not be present or specific, such as loss of appetite, bone pain and fever.

Treatments include drugs, chemotherapy, corticosteroids, radiation or stem cell transplantation.

Multiple myeloma is a cancer that forms in white blood cells called plasma cells. Plasma cells help you fight infections by making antibodies that recognize and attack bacteria. Multiple myeloma causes cancer cells to accumulate in the bone marrow and crowd out healthy blood cells.

Symptoms: fatigue; fracture; bone pain ...

Plasma Cell Disease

Multiple myeloma is one of many diseases that can cause plasma cell problems. Others include:

• Monoclonal gammopathy. This is when your plasma cells make too many copies of an antibody. Multiple myeloma is a form of this disease. Another form, monoclonal gammopathy of unknown significance, may make you more likely to develop multiple myeloma.
• Solitary plasmacytoma. This is like multiple myeloma, but it causes a single abnormal plasma cell growth, not many of them. It can occur inside or outside the bone. It may also increase the risk of multiple myeloma.
• Light chain amyloidosis. This can cause abnormal plasma cells in your bone marrow, but they are fewer than multiple myeloma.
• Waldenstrom macroglobulinemia. This is a type of monoclonal gamma disease and non-Hodgkin's lymphoma (cancer of the lymphatic system). The cancer cells have the characteristics of plasma cells and lymphoid tissues.

Etiology and risk factors of multiple myeloma

Experts are not sure what causes multiple myeloma. However, you are more likely to obtain it if:

• You are over 65 years old
• You are a male
• You are african american
• You have family
• You are overweight or obese
• You are radiated
• You have been exposed to chemicals used in rubber manufacturing, wood processing or fire fighting; or in herbicides

Symptoms of Multiple Myeloma

Early on, you may not notice any symptoms. But as time goes by, you may:

• Bone pain
• Weakness and fatigue
• Weight loss and loss of appetite
• Upset stomach
• constipation
• confusion
• Frequently infected
• thirst
• Weak or numb arms and legs

Diagnosis of Multiple Myeloma

If you perform other blood tests, your doctor may suspect multiple myeloma and display:

• Excessive calcium in the blood (hypercalcemia)
• Too few red blood cells (anemia)
• Kidney problems
• The total protein level in the blood is high, but a level called albumin is low (your doctor may say you have a "globulin gap")

Multiple Myeloma Complications

Multiple myeloma can cause the following problems:

• Bone problems. Your bones will weaken and cause fractures.
• Blood problems. You may have anemia, which means your body does not have enough red blood cells. This can make you tired, pale, and cause heart disease. You may have too few platelets, which makes your blood more difficult to clot.
• Infection. When you have myeloma, your body produces many weak antibodies, which will reject healthy antibodies, making it more difficult for you to fight infection. Lack of white blood cells also weakens your immune system.
• Kidney damage. Myeloma can block the kidneys and prevent them from filtering the way they should. This may cause kidney failure.

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