ORENCIA is a prescription drug for moderate to severe adult rheumatoid arthritis, juvenile idiopathic arthritis and adult psoriatic arthritis.
Abatacept is a drug that can treat autoimmune diseases by interfering with the immune activity of rheumatoid arthritis, such as rheumatoid arthritis T cells. It is a modified antibody. Abatacept is a fusion protein. The Fc region of immunoglobulin IgG1 is fused with the extracellular domain of CTLA-4
Medical uses and fact
In people with autoimmune diseases, the immune system mistakes the body's own cells for intruders and attacks them. Orencia is a prescription drug, It is used to treat the symptoms of rheumatoid arthritis and prevent joint damage caused by these conditions. Abatacept is used as a second-line drug for the treatment of adults with moderate to severe rheumatoid arthritis (RA), And as a front-line agent for people with severe and rapidly progressing RA. It is also used to treat psoriasis
Arthritis and juvenile idiopathic arthritis.
Work of Orencia
Orencia (abatacept) is an injectable biologic drug that slows joint damage and reduces pain from rheumatoid arthritis and other diseases Autoimmune diseases. Orencia works by preventing immune cells in the body, T cells, called T cells, cause swelling and joint damage in arthritis through a process called autoimmune attack.
Contraindications
Abatacept has not been tested in pregnant women, and it is unclear whether it is present in breast milk. When taken in high doses, it can cause birth defects in rodents and spread through rodent breast milk.
Before starting abatacept, people should be checked for tuberculosis and all infections should be removed; the vaccine should be updated before starting to use abatacept. Abacept may interfere with any vaccine people are taking.
It should not be used in combination with anakinra or TNF antagonists. Because of abatacept, anakinra and TNF antagonists suppressing the immune system and using them in combination may greatly increase the risk of serious infections.
The Indications and Usage
ORENCIA combined with methotrexate can treat moderate to severe rheumatoid arthritis
Adult patients who have not responded adequately to previous treatments for one or more disease relief therapies Anti-rheumatic drugs (DMARD), including methotrexate (MTX) or tumor necrosis factor (TNF) -α inhibitors. ORENCIA in combination with methotrexate for the treatment of moderate to severe polyarticular joints Pediatric idiopathic arthritis (JIA) in children 6 years of age and older with insufficient reactivity Other DMARDs including at least one TNF inhibitor.
Important use restrictions
ORENCIA should not be used simultaneously with TNF antagonists. It is not recommended to use ORENCIA simultaneously with other biological rheumatoid arthritis (RA) treatments (such as anakinra).
Side effect
Because clinical trials are conducted under widely varying and controlled conditions, the rate of adverse reactions observed in clinical trials of drugs cannot be directly compared with the incidence in clinical trials of another drug, and may not be predictable in clinical practice The rate of adverse reactions observed in a wider patient population.
Patient consultation information
Inform patients that they should not receive ORENCIA at the same time as TNF antagonists (such as adalimumab, etanercept, and infliximab) because such combination therapy may increase the risk of infection, and they should not interact with other Biological RA treatment also received ORENCIA anakinra because there was insufficient information to evaluate the safety and effectiveness of this combination therapy.
If you want to know more about ORENCIA Click here
Abatacept is a drug that can treat autoimmune diseases by interfering with the immune activity of rheumatoid arthritis, such as rheumatoid arthritis T cells. It is a modified antibody. Abatacept is a fusion protein. The Fc region of immunoglobulin IgG1 is fused with the extracellular domain of CTLA-4
Medical uses and fact
In people with autoimmune diseases, the immune system mistakes the body's own cells for intruders and attacks them. Orencia is a prescription drug, It is used to treat the symptoms of rheumatoid arthritis and prevent joint damage caused by these conditions. Abatacept is used as a second-line drug for the treatment of adults with moderate to severe rheumatoid arthritis (RA), And as a front-line agent for people with severe and rapidly progressing RA. It is also used to treat psoriasis
Arthritis and juvenile idiopathic arthritis.
Work of Orencia
Orencia (abatacept) is an injectable biologic drug that slows joint damage and reduces pain from rheumatoid arthritis and other diseases Autoimmune diseases. Orencia works by preventing immune cells in the body, T cells, called T cells, cause swelling and joint damage in arthritis through a process called autoimmune attack.
Contraindications
Abatacept has not been tested in pregnant women, and it is unclear whether it is present in breast milk. When taken in high doses, it can cause birth defects in rodents and spread through rodent breast milk.
Before starting abatacept, people should be checked for tuberculosis and all infections should be removed; the vaccine should be updated before starting to use abatacept. Abacept may interfere with any vaccine people are taking.
It should not be used in combination with anakinra or TNF antagonists. Because of abatacept, anakinra and TNF antagonists suppressing the immune system and using them in combination may greatly increase the risk of serious infections.
The Indications and Usage
ORENCIA combined with methotrexate can treat moderate to severe rheumatoid arthritis
Adult patients who have not responded adequately to previous treatments for one or more disease relief therapies Anti-rheumatic drugs (DMARD), including methotrexate (MTX) or tumor necrosis factor (TNF) -α inhibitors. ORENCIA in combination with methotrexate for the treatment of moderate to severe polyarticular joints Pediatric idiopathic arthritis (JIA) in children 6 years of age and older with insufficient reactivity Other DMARDs including at least one TNF inhibitor.
Important use restrictions
ORENCIA should not be used simultaneously with TNF antagonists. It is not recommended to use ORENCIA simultaneously with other biological rheumatoid arthritis (RA) treatments (such as anakinra).
Side effect
Because clinical trials are conducted under widely varying and controlled conditions, the rate of adverse reactions observed in clinical trials of drugs cannot be directly compared with the incidence in clinical trials of another drug, and may not be predictable in clinical practice The rate of adverse reactions observed in a wider patient population.
Patient consultation information
Inform patients that they should not receive ORENCIA at the same time as TNF antagonists (such as adalimumab, etanercept, and infliximab) because such combination therapy may increase the risk of infection, and they should not interact with other Biological RA treatment also received ORENCIA anakinra because there was insufficient information to evaluate the safety and effectiveness of this combination therapy.
If you want to know more about ORENCIA Click here
No comments:
Post a Comment